Articles producció científica> Psicologia

Maternal exposure to mixtures of dienestrol, linuron and flutamide. Part I: Feminization effects on male rat offspring

  • Datos identificativos

    Identificador: imarina:6179224
    Handle: http://hdl.handle.net/20.500.11797/imarina6179224
  • Autores:

    Schreiber E
    Garcia T
    González N
    Esplugas R
    Sharma RP
    Torrente M
    Kumar V
    Bovee T
    Katsanou ES
    Machera K
    Domingo JL
    Gómez M
  • Otros:

    Autor según el artículo: Schreiber E; Garcia T; González N; Esplugas R; Sharma RP; Torrente M; Kumar V; Bovee T; Katsanou ES; Machera K; Domingo JL; Gómez M
    Departamento: Enginyeria Química Psicologia
    Autor/es de la URV: Domingo Roig, José Luis / Esplugas Borràs, Roser / Gómez Arnaiz, María Mercedes / Gonzalez Paradell, Nieves / Kumar, Vikas / Torrente Torné, Margarita
    Palabras clave: Sexual-differentiation Reproductive development Nipple retention Mixtures Male rats Liquid-phase microextraction Linuron Flutamide Feminization effects Extraction sorbent Estrogenic compounds Endocrine disruptors Dienestrol Anti-androgens Anogenital distance Androgen receptor male rats linuron flutamide feminization effects dienestrol
    Resumen: © 2020 The Authors Exposure to endocrine-disrupting compounds (EDCs) during pregnancy can result in negative health effects in later generations, including sex changes and feminization. The present study assessed the feminization effects on male offspring rats of three EDCs: Dienestrol (DIES), Linuron (LIN), and Flutamide (FLU). Sexually mature female rats were exposed from gestation day (GD) 6 until postnatal day (PND) 21 to: 0.37, 0.75, 1.5, 3.12 or 6.25 μg/kg/day of DIES, 1.5, 3, 6, 12.5, 25 or 50 mg/kg/day of LIN, 3.5, 6.7, 12.5, 25 or 50 mg/kg/day of FLU, and the following mixtures: FLU + DIES (mg/kg/day+μg/kg/day), 3.5 + 0.37, or 3.5 + 3, 25 + 0.37, or 25 + 3; FLU + LIN (mg/kg/day + mg/kg/day), 3.5 + 12.5, or 25 + 12.5; and DIES + LIN (μg/kg/day + mg/kg/day), 0.37 + 12.5, or 3 + 12.5. Anogenital distance (AGD), nipple retention (NR) and cryptorchidism were evaluated. FLU produced a decrease of AGD, an increase of NR, and an increase of cryptorchidism at the highest dose. None of these three endpoints were significantly affected by LIN or DIES treatments alone. Combinations of FLU + LIN and FLU + DIES increased NR, and decreased AGD, while DIES + LIN did not produce any effects in male pups. Results show that FLU is able to induce feminization in male pups, while binary combinations of LIN and DIES did not modify the effects produced by FLU.
    Áreas temáticas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 02786915
    Direcció de correo del autor: nieves.gonzalez@urv.cat vikas.kumar@urv.cat margarita.torrente@urv.cat joseluis.domingo@urv.cat
    Identificador del autor: 0000-0003-4134-016X 0000-0002-9795-5967 0000-0002-8901-6345 0000-0001-6647-9470
    Fecha de alta del registro: 2023-02-22
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S0278691520301447
    URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Food And Chemical Toxicology. 139 (111256): 111256-
    Referencia de l'ítem segons les normes APA: Schreiber E; Garcia T; González N; Esplugas R; Sharma RP; Torrente M; Kumar V; Bovee T; Katsanou ES; Machera K; Domingo JL; Gómez M (2020). Maternal exposure to mixtures of dienestrol, linuron and flutamide. Part I: Feminization effects on male rat offspring. Food And Chemical Toxicology, 139(111256), 111256-. DOI: 10.1016/j.fct.2020.111256
    DOI del artículo: 10.1016/j.fct.2020.111256
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Food Science,Food Science & Technology,Medicine (Miscellaneous),Toxicology
    Sexual-differentiation
    Reproductive development
    Nipple retention
    Mixtures
    Male rats
    Liquid-phase microextraction
    Linuron
    Flutamide
    Feminization effects
    Extraction sorbent
    Estrogenic compounds
    Endocrine disruptors
    Dienestrol
    Anti-androgens
    Anogenital distance
    Androgen receptor
    male rats
    linuron
    flutamide
    feminization effects
    dienestrol
    Toxicology
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Ensino
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física
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