Articles producció científica> Psicologia

Composition of gut microbiota in children with autism spectrum disorder: A systematic review and meta-analysis

  • Datos identificativos

    Identificador: imarina:6185842
    Autores:
    Iglesias–vázquez LRiba GVGArija VCanals J
    Resumen:
    © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Background: Autism spectrum disorder (ASD) is a public health problem and has a prevalence of 0.6%–1.7% in children. As well as psychiatric symptoms, dysbiosis and gastrointestinal comorbidities are also frequently reported. The gut–brain microbiota axis suggests that there is a form of communication between microbiota and the brain underlying some neurological disabilities. The aim of this study is to describe and compare the composition of gut microbiota in children with and without ASD. Methods: Electronic databases were searched as far as February 2020. Meta-analyses were performed using RevMan5.3 to estimate the overall relative abundance of gut bacteria belonging to 8 phyla and 17 genera in children with ASD and controls. Results: We included 18 studies assessing a total of 493 ASD children and 404 controls. The microbiota was mainly composed of the phyla Bacteroidetes, Firmicutes, and Actinobacteria, all of which were more abundant in the ASD children than in the controls. Children with ASD showed a significantly higher abundance of the genera Bacteroides, Parabacteroides, Clostridium, Faecalibacterium, and Phascolarctobacterium and a lower percentage of Coprococcus and Bifidobacterium. Discussion: This meta-analysis suggests that there is a dysbiosis in ASD children which may influence the development and severity of ASD symptomatology. Further studies are required in order to obtain stronger evidence of the effectiveness of pre-or probiotics in reducing autistic behaviors.
  • Otros:

    Autor según el artículo: Iglesias–vázquez L; Riba GVG; Arija V; Canals J
    Departamento: Psicologia Ciències Mèdiques Bàsiques
    Autor/es de la URV: Arija Val, Maria Victoria / Canals Sans, Josefa / Iglesias Vazquez, Lucia
    Palabras clave: Systematic review and meta-analysis Statement Prevalence Microflora Gut microbiota Gastrointestinal microbiota Dysbiosis Children Autism spectrum disorder Asd Adolescents Acids gut microbiota dysbiosis children autism spectrum disorder asd adolescents
    Resumen: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Background: Autism spectrum disorder (ASD) is a public health problem and has a prevalence of 0.6%–1.7% in children. As well as psychiatric symptoms, dysbiosis and gastrointestinal comorbidities are also frequently reported. The gut–brain microbiota axis suggests that there is a form of communication between microbiota and the brain underlying some neurological disabilities. The aim of this study is to describe and compare the composition of gut microbiota in children with and without ASD. Methods: Electronic databases were searched as far as February 2020. Meta-analyses were performed using RevMan5.3 to estimate the overall relative abundance of gut bacteria belonging to 8 phyla and 17 genera in children with ASD and controls. Results: We included 18 studies assessing a total of 493 ASD children and 404 controls. The microbiota was mainly composed of the phyla Bacteroidetes, Firmicutes, and Actinobacteria, all of which were more abundant in the ASD children than in the controls. Children with ASD showed a significantly higher abundance of the genera Bacteroides, Parabacteroides, Clostridium, Faecalibacterium, and Phascolarctobacterium and a lower percentage of Coprococcus and Bifidobacterium. Discussion: This meta-analysis suggests that there is a dysbiosis in ASD children which may influence the development and severity of ASD symptomatology. Further studies are required in order to obtain stronger evidence of the effectiveness of pre-or probiotics in reducing autistic behaviors.
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20726643
    Direcció de correo del autor: lucia.iglesias@urv.cat victoria.arija@urv.cat josefa.canals@urv.cat lucia.iglesias@urv.cat
    Identificador del autor: 0000-0001-7131-4144 0000-0002-1758-0975 0000-0002-6209-9558 0000-0001-7131-4144
    Fecha de alta del registro: 2023-02-19
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2072-6643/12/3/792
    Referencia al articulo segun fuente origial: Nutrients. 12 (3):
    Referencia de l'ítem segons les normes APA: Iglesias–vázquez L; Riba GVG; Arija V; Canals J (2020). Composition of gut microbiota in children with autism spectrum disorder: A systematic review and meta-analysis. Nutrients, 12(3), -. DOI: 10.3390/nu12030792
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.3390/nu12030792
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Systematic review and meta-analysis
    Statement
    Prevalence
    Microflora
    Gut microbiota
    Gastrointestinal microbiota
    Dysbiosis
    Children
    Autism spectrum disorder
    Asd
    Adolescents
    Acids
    gut microbiota
    dysbiosis
    children
    autism spectrum disorder
    asd
    adolescents
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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