Autor según el artículo: Romeu M; Nogues R; Marcas L; Snchez-Martos V; Mulero M; Martinez-Vea A; Mallol J; Giralt M

Departamento: Medicina i Cirurgia Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques

Autor/es de la URV: Giralt Batista, Montserrat / MALLOL MIRÓN, JORGE / Martínez Vea, Alberto / Mulero Abellán, Miguel / Nogués Llort, Maria Rosa / Romeu Ferran, Marta / Sánchez Martos, Vanessa

Palabras clave: Insuficiencia renal crónica Estrès oxidatiu

Resumen: Background. Oxidative stress is related to several diseases, including chronic renal insufficiency. The disequilibrium in the oxidant-antioxidant balance is the result of several metabolic changes. The majority of studies to-date have evaluated the grade of oxidative stress with a single biomarker, or a very limited number of them. Findings. The present study used several important biomarkers to establish a score relating to oxidative stress status (glutathione S-transferase, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, reduced and oxidized glutathione, thiobarbituric acid reactive substances and hemolysis test). The score of oxidative stress (SOS) was then applied to a group of patients with renal insufficiency not on hemodialysis, and compared to healthy control individuals. The score for patients with chronic renal insufficiency was significantly different from that of the healthy control group (0.62 1.41 vs. -0.05 0.94; p < 0.001). The comparison between patients with chronic renal insufficiency and control individuals showed significant differences with respect to changes in the enzymatic antioxidant systems (glutathione S-transferase, glutathione reductase), non-enzymatic antioxidant system (oxidized glutathione) and oxidizability (hemolysis test) indicating significant oxidative stress associated with chronic renal insufficiency. Conclusions. Patients with chronic renal insufficiency not on hemodialysis are susceptible to oxidative stress. The mechanisms that underlie this status are the consequence of changes in glutathione and related enzymes. The SOS scoring system is a useful biochemical parameter to evaluate the influence of oxidative stress on the clinical status of these patients. © 2010 Giralt et al; licensee BioMed Central Ltd.

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Multidisciplinary sciences Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Geografía General medicine General biochemistry,genetics and molecular biology Farmacia Engenharias iv Engenharias iii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Antropologia / arqueologia Administração pública e de empresas, ciências contábeis e turismo

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 17560500

Direcció de correo del autor: vanessa.sanchez@urv.cat alberto.martinez@urv.cat mariarosa.nogues@urv.cat marta.romeu@urv.cat miquel.mulero@urv.cat vanessa.sanchez@urv.cat montse.giralt@urv.cat

Identificador del autor: 0000-0002-0819-8096 0000-0003-4626-5672 0000-0002-2131-1858 0000-0002-7073-577X

Fecha de alta del registro: 2023-02-26

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-3-20

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Bmc Research Notes. 3 20-

Referencia de l'ítem segons les normes APA: Romeu M; Nogues R; Marcas L; Snchez-Martos V; Mulero M; Martinez-Vea A; Mallol J; Giralt M (2010). Evaluation of oxidative stress biomarkers in patients with chronic renal failure: A case control study. Bmc Research Notes, 3(), 20-. DOI: 10.1186/1756-0500-3-20

DOI del artículo: 10.1186/1756-0500-3-20

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2010

Tipo de publicación: Journal Publications