Autor según el artículo: Vicens C; Socias I; Mateu C; Leiva A; Bejarano F; Sempere E; Basora J; Palop V; Mengual M; Beltran J; Aragonès E; Lera G; Folch S; Pĩol J; Esteva M; Roca M; Arenas A; Del Mar Sureda M; Campoamor F; Fiol F
Departamento: Medicina i Cirurgia
Autor/es de la URV: Basora Gallisa, Josep
Resumen: Background: Although benzodiazepines are effective, long-term use is not recommended because of potential adverse effects; the risks of tolerance and dependence; and an increased risk of hip fractures, motor vehicle accidents, and memory impairment. The estimated prevalence of long-term benzodiazepine use in the general population is about 2,2 to 2,6%, is higher in women and increases steadily with age. Interventions performed by General Practitioners may help patients to discontinue long-term benzodiazepine use. We have designed a trial to evaluate the effectiveness and safety of two brief general practitioner-provided interventions, based on gradual dose reduction, and will compare the effectiveness of these interventions with that of routine clinical practice. Methods/Design. In a three-arm cluster randomized controlled trial, general practitioners will be randomly allocated to: a) a group in which the first patient visit will feature a structured interview, followed by visits every 2-3 weeks to the end of dose reduction; b) a group in which the first patient visit will feature a structured interview plus delivery of written instructions to self-reduce benzodiazepine dose, or c) routine care. Using a computerized pharmaceutical prescription database, 495 patients, aged 18-80 years, taking benzodiazepine for at least 6 months, will be recruited in primary care health districts of three regions of Spain (the Balearic Islands, Catalonia, and Valencia). The primary outcome will be benzodiazepine use at 12 months. The secondary outcomes will include measurements of anxiety and depression symptoms, benzodiazepine dependence, quality of sleep, and alcohol consumption. Discussion. Although some interventions have been shown to be effective in reducing benzodiazepine consumption by long-term users, the clinical relevance of such interventions is limited by their complexity. This randomized trial will compare the effectiveness and safety of two complex stepped care interventions with that of routine care in a study with sufficient statistical power to detect clinically relevant differences. © 2011 Vicens et al; licensee BioMed Central Ltd.
Áreas temáticas: Saúde coletiva Psicología Primary health care Odontología Medicine, general & internal Medicina ii Interdisciplinar Family practice Enfermagem
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14712296
Direcció de correo del autor: josep.basora@urv.cat josep.basora@urv.cat
Fecha de alta del registro: 2023-02-19
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Referencia al articulo segun fuente origial: Bmc Family Practice. 12 23-
Referencia de l'ítem segons les normes APA: Vicens C; Socias I; Mateu C; Leiva A; Bejarano F; Sempere E; Basora J; Palop V; Mengual M; Beltran J; Aragonès E; Lera G; Folch S; Pĩol J; Esteva M; R (2011). Comparative efficacy of two primary care interventions to assist withdrawal from long term benzodiazepine use: A protocol for a clustered, randomized clinical trial. Bmc Family Practice, 12(), 23-. DOI: 10.1186/1471-2296-12-23
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2011
Tipo de publicación: Journal Publications
Repositori URV