Autor según el artículo: Molinar-Toribio E; Pérez-Jiménez J; Ramos-Romero S; Romeu M; Giralt M; Taltavull N; Muñoz-Cortes M; Jáuregui O; Méndez L; Medina I; Torres J

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: Giralt Batista, Montserrat / Muñoz Cortés, Mónica / Romeu Ferran, Marta / Taltavull Anglada, Núria

Palabras clave: Spontaneously hypertensive rats Spontaneously hypertensive obese rats Omega-3 pufa N-3 pufa Metabolic syndrome Epa/dha Cardiovascular disease

Resumen: Copyright © The Authors 2015. The increasing incidence of the metabolic syndrome (MetS), a combination of risk factors before the onset of CVD and type 2 diabetes, encourages studies on the role of functional food components such as long-chain n-3 PUFA as preventive agents. In the present study, we explore the effect of EPA and DHA supplementation in different proportions on spontaneously hypertensive obese (SHROB) rats, a model for the MetS in a prediabetic state with mild oxidative stress. SHROB rats were randomised into four groups (n 7), each supplemented with EPA/DHA at ratios of 1:1, 2:1 and 1:2, or soyabean oil as the control for 13 weeks. The results showed that in all the proportions tested, EPA/DHA supplementation significantly lowered total and LDL-cholesterol concentrations, compared with those of the control group. EPA/DHA supplementation at the ratios of 1:1 and 2:1 significantly decreased inflammation (C-reactive protein levels) and lowered oxidative stress (decreased excretion of urinary isoprostanes), mainly at the ratio of 1:2. The activity of antioxidant enzymes increased in erythrocytes, abdominal fat and kidneys, with magnitudes depending on the EPA:DHA ratio. PUFA mixtures from fish affected different MetS markers of CVD risk factors in SHROB rats, depending on the ratios of EPA/DHA supplementation. The activation of endogenous defence systems may be related to the reduction of inflammation and oxidative stress.

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Administração pública e de empresas, ciências contábeis e turismo

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14752662

Direcció de correo del autor: monica.munoz@urv.cat nuria.taltavull@urv.cat marta.romeu@urv.cat montse.giralt@urv.cat

Identificador del autor: 0000-0002-3340-2650 0000-0002-2131-1858 0000-0002-7073-577X

Fecha de alta del registro: 2023-02-19

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-n3-pufa-supplementation-at-different-epadha-ratios-on-the-spontaneously-hypertensive-obese-rat-model-of-the-metabolic-syndrome/D47DD8D947BBCC59C1310A797A2A14A7

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: British Journal Of Nutrition. 113 (6): 878-887

Referencia de l'ítem segons les normes APA: Molinar-Toribio E; Pérez-Jiménez J; Ramos-Romero S; Romeu M; Giralt M; Taltavull N; Muñoz-Cortes M; Jáuregui O; Méndez L; Medina I; Torres J (2015). Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome. British Journal Of Nutrition, 113(6), 878-887. DOI: 10.1017/S0007114514004437

DOI del artículo: 10.1017/S0007114514004437

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2015

Tipo de publicación: Journal Publications