Autor según el artículo: Ribas-Latre A; Del Bas JM; Baselga-Escudero L; Casanova E; Arola-Arnal A; Salvadó MJ; Arola L; Bladé C
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Arola Arnal, Anna / Arola Fernández, Lluís / Arola Ferrer, Luis Maria / BASELGA ESCUDERO, LAURA / BLADÉ SEGARRA, MARIA CINTA / CASANOVA VALLVÉ, ESTER / Ribas Latre, Aleix / Salvadó Rovira, Maria Josepa
Palabras clave: Xenohormesis Metabolomics Melatonin Flavonoids Bmal1 metabolomics melatonin flavonoids bmal1
Resumen: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Scope: Circadian rhythms allow organisms to anticipate and adapt to environmental changes, and food components can adjust internal rhythms. Proanthocyanidins improve cardiovascular risk factors that exhibit circadian oscillations. Therefore, the aim of the current study was to determine whether proanthocyanidins can modulate body rhythms. Methods and results: Male Wistar rats were orally gavaged with 250 mg grape seed proanthocyanidin extract (GSPE)/kg body weight at zeitgeber time (ZT) 0 (light on). Phenotypic biorhythm was evaluated by measuring the concentration of plasma melatonin and metabolites, using MNR-metabolomics, at several ZT. Remarkably, GSPE treatment maintained nocturnal melatonin levels at ZT3 and altered the oscillations of some metabolites in plasma. Quantification of expression of clock-core (Clock, Bmal1, Per2, Rorα, Rev-erbα) and clock-controlled (Nampt) genes in the hypothalamus by RT-PCR showed that this phenotypic alteration was concomitant with the modulation of the expression pattern of Bmal1 and Nampt. However, GSPE did not modulate the nocturnal expression of clock genes when administered at ZT12 (light off). Conclusion: PAs could have chronobiological properties, although their activity depends largely on the time of administration.
Grupo de investigación: Grup de Recerca en Nutrigenòmica
Áreas temáticas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16134125
Direcció de correo del autor: lluis.arola@estudiants.urv.cat lluis.arola@estudiants.urv.cat anna.arola@urv.cat lluis.arola@urv.cat
Identificador del autor: 0000-0001-6529-1345 0000-0003-2767-1974
Fecha de alta del registro: 2024-09-28
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201400571
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Molecular Nutrition & Food Research. 59 (5): 865-878
Referencia de l'ítem segons les normes APA: Ribas-Latre A; Del Bas JM; Baselga-Escudero L; Casanova E; Arola-Arnal A; Salvadó MJ; Arola L; Bladé C (2015). Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats. Molecular Nutrition & Food Research, 59(5), 865-878. DOI: 10.1002/mnfr.201400571
DOI del artículo: 10.1002/mnfr.201400571
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2015
Tipo de publicación: Journal Publications