Autor según el artículo: Siqueira J; Sutton D; García D; Gené J; Thomson P; Wiederhold N; Guarro J

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: García Sánchez, Dania / Gené Díaz, Josepa / Guarro Artigas, Josep / ZEN SIQUEIRA, JOAO PAULO

Palabras clave: Taxonomy Sydowii Penicillium Onychomycosis Multilocus phylogeny Metabolites Infection Identification Endolichenic fungus Aspergilli Ascomycetes Antufungal activity Amphotericin-b Agents multilocus phylogeny aspergilli ascomycetes antufungal activity

Resumen: © 2016 British Mycological Society Aspergillus section Versicolores includes species of clinical relevance and many others that have been poorly studied but are occasionally found in clinical samples. The aim of this study was to investigate, using a multilocus phylogenetic approach, the spectrum of species of the section Versicolores and to determine their in vitro antifungal susceptibility. The study was based on a set of 77 clinical isolates from different USA medical centres, which had been previously identified as belonging to this section. The genetic markers used were internal transcribed spacer (ITS), β-tubulin (BenA), calmodulin (CaM), and RNA polymerase II second largest subunit (RPB2), and the drugs tested, following the CLSI guidelines, were amphotericin B (AMB), itraconazole, posaconazole, voriconazole, anidulafungin, caspofungin, micafungin, terbinafine (TBF), and flucytosine (5FC). The most frequent species were Aspergillus sydowii (26 %), Aspergillus creber (22 %), and Aspergillus amoenus (18.2 %), followed by Aspergillus protuberus (13 %), Aspergillus jensenii (10.4 %), and Aspergillus tabacinus (5.2 %); while Aspergillus cvjetkovicii, Aspergillus fructus, Aspergillus puulaauensis, and Aspergillus versicolor were represented by only one isolate each (1.3 %). This is the first time that A. jensenii and A. puulaauensis have been reported from clinical samples. Considering the high number of isolates identified as belonging to this fungal group in this study, its clinical relevance should not be overlooked. Aspergillus versicolor, traditionally considered one of the most common species in this section in a clinical setting, was only rarely recovered in our study. The in vitro antifungal results showed that echinocandins and TBF were the most potent drugs, the azoles showed variable results, AMB was poorly active, and 5FC was the less active.

Grupo de investigación: Unitat de Micologia i Microbiologia Ambiental

Áreas temáticas: Zootecnia / recursos pesqueiros Química Plant science Mycology Medicina veterinaria Medicina ii Medicina i Interdisciplinar Infectious diseases Genetics Farmacia Engenharias iv Economia Ecology, evolution, behavior and systematics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 18786146

Direcció de correo del autor: josep.guarro@urv.cat josepa.gene@urv.cat dania.garcias@urv.cat

Identificador del autor: 0000-0002-7839-7568 0000-0001-6195-9299 0000-0003-2397-1646

Fecha de alta del registro: 2023-05-20

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S187861461600043X?via%3Dihub

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Fungal Biology. 120 (11): 1458-1467

Referencia de l'ítem segons les normes APA: Siqueira J; Sutton D; García D; Gené J; Thomson P; Wiederhold N; Guarro J (2016). Species diversity of Aspergillus section Versicolores in clinical samples and antifungal susceptibility. Fungal Biology, 120(11), 1458-1467. DOI: 10.1016/j.funbio.2016.02.006

DOI del artículo: 10.1016/j.funbio.2016.02.006

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2016

Tipo de publicación: Journal Publications