Articles producció científica> Medicina i Cirurgia

Risk of cause-specific death in individuals with diabetes: A competing risks analysis

  • Datos identificativos

    Identificador: imarina:6388899
    Handle: https://hdl.handle.net/20.500.11797/imarina6388899
    Autores:
    Miguel Baena-Diez, JosePenafiel, JuditSubirana, IsaacRamos, RafelElosua, RobertoMarin-Ibanez, AlejandroJesus Guembe, MariaRigo, FernandoJose Tormo-Diaz, MariaMoreno-Iribas, ConchiJosep Cabre, JoanSegura, AntonioGarcia-Lareo, ManelGomez de la Carnara, AgustinLapetra, JoseQuesada, MiguelMarrugat, JaumeJose Medrano, MariaBerjon, JesusFrontera, GuiemGavrila, DianaBarricarte, AurelioBasora, JosepMaria Garcia, JosePavone, Natalia CLora-Pablos, DavidMayora, EduardoFranch, JosepMata, ManelCastell, ConxaFrances, AlbertGrau, Maria
    Resumen:
    © 2016 by the American Diabetes Association. OBJECTIVE Diabetes is a common cause of shortened life expectancy. We aimed to assess the association between diabetes and cause-specific death. RESEARCH DESIGN AND METHODS We used the pooled analysis of individual data from 12 Spanish population cohorts with 10-year follow-up. Participants had no previous history of cardiovascular diseases and were 35-79 years old. Diabetes status was self-reported or defined as glycemia >125mg/dL at baseline. Vital status and causes of death were ascertained by medical records review and linkage with the official death registry. The hazard ratios and cumulative mortality function were assessed with two approaches, with and without competing risks: proportional subdistribution hazard (PSH) and cause-specific hazard (CSH), respectively. Multivariate analyses were fitted for cardiovascular, cancer, and noncardiovascular noncancer deaths. RESULTS We included 55,292 individuals (15.6% with diabetes and overall mortality of 9.1%). The adjusted hazard ratios showed that diabetes increased mortality risk: 1) cardiovascular death, CSH = 2.03 (95% CI 1.63-2.52) and PSH = 1.99 (1.60-2.49) inmen; and CSH = 2.28 (1.75-2.97) and PSH = 2.23 (1.70-2.91) in women; 2) cancer death, CSH = 1.37 (1.13-1.67) and PSH = 1.35 (1.10-1.65) in men; and CSH = 1.68 (1.29-2.20) and PSH = 1.66 (1.25-2.19) in women; and 3) noncardiovascular noncancer death, CSH = 1.53 (1.23-1.91) and PSH = 1.50 (1.20-1.89) inmen; and CSH = 1.89 (1.43-2.48) and PSH = 1.84 (1.39-2.45) in women. In all instances, the cumulative mortality function was significantly higher in individuals with diabetes. CONCLUSIONS Diabetes is associated with premature death from cardiovascular disease, cancer, and noncardiovascular noncancer causes. The use of

  • Otros:

    Autor según el artículo: Miguel Baena-Diez, Jose; Penafiel, Judit; Subirana, Isaac; Ramos, Rafel; Elosua, Roberto; Marin-Ibanez, Alejandro; Jesus Guembe, Maria; Rigo, Fernando; Jose Tormo-Diaz, Maria; Moreno-Iribas, Conchi; Josep Cabre, Joan; Segura, Antonio; Garcia-Lareo, Manel; Gomez de la Carnara, Agustin; Lapetra, Jose; Quesada, Miguel; Marrugat, Jaume; Jose Medrano, Maria; Berjon, Jesus; Frontera, Guiem; Gavrila, Diana; Barricarte, Aurelio; Basora, Josep; Maria Garcia, Jose; Pavone, Natalia C; Lora-Pablos, David; Mayora, Eduardo; Franch, Josep; Mata, Manel; Castell, Conxa; Frances, Albert; Grau, Maria
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Basora Gallisa, Josep / Cabré Olivé, Joan / Cabre Vila, Juan Jose
    Palabras clave: Myocardial-infarction Mortality Metaanalysis Mellitus Hazards Glucose Coronary-heart-disease Complications Cardiovascular risk All-cause
    Resumen: © 2016 by the American Diabetes Association. OBJECTIVE Diabetes is a common cause of shortened life expectancy. We aimed to assess the association between diabetes and cause-specific death. RESEARCH DESIGN AND METHODS We used the pooled analysis of individual data from 12 Spanish population cohorts with 10-year follow-up. Participants had no previous history of cardiovascular diseases and were 35-79 years old. Diabetes status was self-reported or defined as glycemia >125mg/dL at baseline. Vital status and causes of death were ascertained by medical records review and linkage with the official death registry. The hazard ratios and cumulative mortality function were assessed with two approaches, with and without competing risks: proportional subdistribution hazard (PSH) and cause-specific hazard (CSH), respectively. Multivariate analyses were fitted for cardiovascular, cancer, and noncardiovascular noncancer deaths. RESULTS We included 55,292 individuals (15.6% with diabetes and overall mortality of 9.1%). The adjusted hazard ratios showed that diabetes increased mortality risk: 1) cardiovascular death, CSH = 2.03 (95% CI 1.63-2.52) and PSH = 1.99 (1.60-2.49) inmen; and CSH = 2.28 (1.75-2.97) and PSH = 2.23 (1.70-2.91) in women; 2) cancer death, CSH = 1.37 (1.13-1.67) and PSH = 1.35 (1.10-1.65) in men; and CSH = 1.68 (1.29-2.20) and PSH = 1.66 (1.25-2.19) in women; and 3) noncardiovascular noncancer death, CSH = 1.53 (1.23-1.91) and PSH = 1.50 (1.20-1.89) inmen; and CSH = 1.89 (1.43-2.48) and PSH = 1.84 (1.39-2.45) in women. In all instances, the cumulative mortality function was significantly higher in individuals with diabetes. CONCLUSIONS Diabetes is associated with premature death from cardiovascular disease, cancer, and noncardiovascular noncancer causes. The use of CSH and PSH provides a comprehensive view of mortality dynamics in a population with diabetes.
    Áreas temáticas: Saúde coletiva Odontología Nutrição Medicina iii Medicina ii Medicina i Internal medicine Interdisciplinar General medicine Engenharias iv Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i Biotecnología Antropologia / arqueologia Advanced and specialized nursing
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 01495992
    Direcció de correo del autor: juanjose.cabre@urv.cat josep.basora@urv.cat josep.basora@urv.cat
    Identificador del autor: 0000-0003-1082-6861
    Fecha de alta del registro: 2024-10-12
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Diabetes Care. 39 (11): 1987-1995
    Referencia de l'ítem segons les normes APA: Miguel Baena-Diez, Jose; Penafiel, Judit; Subirana, Isaac; Ramos, Rafel; Elosua, Roberto; Marin-Ibanez, Alejandro; Jesus Guembe, Maria; Rigo, Fernando (2016). Risk of cause-specific death in individuals with diabetes: A competing risks analysis. Diabetes Care, 39(11), 1987-1995. DOI: 10.2337/dc16-0614
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2016
    Tipo de publicación: Journal Publications

  • Palabras clave:

    Advanced and Specialized Nursing,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Internal Medicine
    Myocardial-infarction
    Mortality
    Metaanalysis
    Mellitus
    Hazards
    Glucose
    Coronary-heart-disease
    Complications
    Cardiovascular risk
    All-cause
    Saúde coletiva
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Internal medicine
    Interdisciplinar
    General medicine
    Engenharias iv
    Enfermagem
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Antropologia / arqueologia
    Advanced and specialized nursing

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