Autor según el artículo: Nadal L; Garcia N; Hurtado E; Simó A; Tomàs M; Lanuza M; Cilleros V; Tomàs J

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: Cilleros Mañé, Víctor / Garcia Sancho, Maria de les Neus / HURTADO CABALLERO, ERICA / Lanuza Escolano, María Angel / NADAL MAGRIÑÀ, LAURA / SIMÓ OLLÉ, ANNA / Tomás Ferré, José Maria / Tomas Marginet, Marta

Palabras clave: Trkb receptor Synapse elimination Presynaptic muscarinic acetylcholine receptors Neuromuscular junction Motor nerve terminal Cholinergic synapses trkb receptor presynaptic muscarinic acetylcholine receptors neuromuscular junction motor nerve terminal cholinergic synapses

Resumen: © 2017 Nadal, Garcia, Hurtado, Simó, Tomàs, Lanuza, Cilleros and Tomàs. The development of the nervous system involves the overproduction of synapses but connectivity is refined by Hebbian activity-dependent axonal competition. The newborn skeletal muscle fibers are polyinnervated but, at the end of the competition process, some days later, become innervated by a single axon. We used quantitative confocal imaging of the autofluorescent axons from transgenic B6.Cg-Tg (Thy1-YFP)16 Jrs/J mice to investigate the possible cooperation of the muscarinic autoreceptors (mAChR, M1-, M2- and M4-subtypes) and the tyrosine kinase B (TrkB) receptor in the control of axonal elimination after the mice Levator auris longus (LAL) muscle had been exposed to several selective antagonist of the corresponding receptor pathways in vivo. Our previous results show that M1, M2 and TrkB signaling individually increase axonal loss rate around P9. Here we show that although the M1 and TrkB receptors cooperate and add their respective individual effects to increase axonal elimination rate even more, the effect of the M2 receptor is largely independent of both M1 and TrkB receptors. Thus both, cooperative and non-cooperative signaling mechanisms contribute to developmental synapse elimination.

Áreas temáticas: Saúde coletiva Química Psicología Nutrição Neurosciences Medicina veterinaria Medicina ii Medicina i Interdisciplinar Geriatrics & gerontology Engenharias iv Educação física Cognitive neuroscience Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade Aging

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 16634365

Direcció de correo del autor: victor.cilleros@urv.cat marta.tomas@urv.cat mariaangel.lanuza@urv.cat josepmaria.tomas@urv.cat victor.cilleros@urv.cat

Identificador del autor: 0000-0001-5690-9932 0000-0002-4151-1697 0000-0003-4795-4103 0000-0002-0406-0006 0000-0001-5690-9932

Fecha de alta del registro: 2023-09-02

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fnagi.2017.00024/full

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Frontiers In Aging Neuroscience. 9 (FEB): 24-

Referencia de l'ítem segons les normes APA: Nadal L; Garcia N; Hurtado E; Simó A; Tomàs M; Lanuza M; Cilleros V; Tomàs J (2017). Presynaptic muscarinic acetylcholine receptors and TrkB receptor cooperate in the elimination of redundant motor nerve terminals during development. Frontiers In Aging Neuroscience, 9(FEB), 24-. DOI: 10.3389/fnagi.2017.00024

DOI del artículo: 10.3389/fnagi.2017.00024

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2017

Tipo de publicación: Journal Publications