Autor según el artículo: Tomàs J; Garcia N; Lanuza M; Santafé M; Tomàs M; Nadal L; Hurtado E; Simó A; Cilleros V

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: Cilleros Mañé, Víctor / Garcia Sancho, Maria de les Neus / HURTADO CABALLERO, ERICA / Lanuza Escolano, María Angel / NADAL MAGRIÑÀ, LAURA / Santafé Martínez, Manuel / SIMÓ OLLÉ, ANNA / Tomás Ferré, José Maria / Tomas Marginet, Marta

Palabras clave: Voltage-dependent calcium channels Trkb Protein kinases Postnatal synapse elimination Pkc Muscarinic acetylcholine receptors Axonal competition Acetylcholine release trkb protein kinases postnatal synapse elimination pkc muscarinic acetylcholine receptors axonal competition acetylcholine release

Resumen: © 2017 Tomàs, Garcia, Lanuza, Santafé, Tomàs, Nadal, Hurtado, Simó and Cilleros. During the histogenesis of the nervous system a lush production of neurons, which establish an excessive number of synapses, is followed by a drop in both neurons and synaptic contacts as maturation proceeds. Hebbian competition between axons with different activities leads to the loss of roughly half of the neurons initially produced so connectivity is refined and specificity gained. The skeletal muscle fibers in the newborn neuromuscular junction (NMJ) are polyinnervated but by the end of the competition, 2 weeks later, the NMJ are innervated by only one axon. This peripheral synapse has long been used as a convenient model for synapse development. In the last few years, we have studied transmitter release and the local involvement of the presynaptic muscarinic acetylcholine autoreceptors (mAChR), adenosine autoreceptors (AR) and trophic factor receptors (TFR, for neurotrophins and trophic cytokines) during the development of NMJ and in the adult. This review article brings together previously published data and proposes a molecular background for developmental axonal competition and loss. At the end of the first week postnatal, these receptors modulate transmitter release in the various nerve terminals on polyinnervated NMJ and contribute to axonal competition and synapse elimination.

Áreas temáticas: Neurosciences Molecular biology Medicina ii Ciências biológicas ii Cellular and molecular neuroscience

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 16625099

Direcció de correo del autor: victor.cilleros@urv.cat marta.tomas@urv.cat manuel.santafe@urv.cat mariaangel.lanuza@urv.cat josepmaria.tomas@urv.cat victor.cilleros@urv.cat

Identificador del autor: 0000-0001-5690-9932 0000-0002-4151-1697 0000-0002-5462-5108 0000-0003-4795-4103 0000-0002-0406-0006 0000-0001-5690-9932

Fecha de alta del registro: 2023-09-02

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fnmol.2017.00132/full

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Frontiers In Molecular Neuroscience. 10 132-

Referencia de l'ítem segons les normes APA: Tomàs J; Garcia N; Lanuza M; Santafé M; Tomàs M; Nadal L; Hurtado E; Simó A; Cilleros V (2017). Presynaptic membrane receptors modulate ACh release, axonal competition and synapse elimination during neuromuscular junction development. Frontiers In Molecular Neuroscience, 10(), 132-. DOI: 10.3389/fnmol.2017.00132

DOI del artículo: 10.3389/fnmol.2017.00132

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2017

Tipo de publicación: Journal Publications