Articles producció científica> Bioquímica i Biotecnologia

The microbiota–gut–brain axis in obesity

  • Datos identificativos

    Identificador: imarina:6389273
    Autores:
    Torres-Fuentes, CSchellekens, HDinan, TGCryan, JF
    Resumen:
    © 2017 Elsevier Ltd Changes in microbial diversity and composition are increasingly associated with several disease states including obesity and behavioural disorders. Obesity-associated microbiota alter host energy harvesting, insulin resistance, inflammation, and fat deposition. Additionally, intestinal microbiota can regulate metabolism, adiposity, homoeostasis, and energy balance as well as central appetite and food reward signalling, which together have crucial roles in obesity. Moreover, some strains of bacteria and their metabolites might target the brain directly via vagal stimulation or indirectly through immune-neuroendocrine mechanisms. Therefore, the gut microbiota is becoming a target for new anti-obesity therapies. Further investigations are needed to elucidate the intricate gut-microbiota–host relationship and the potential of gut-microbiota-targeted strategies, such as dietary interventions and faecal microbiota transplantation, as promising metabolic therapies that help patients to maintain a healthy weight throughout life.
  • Otros:

    Autor según el artículo: Torres-Fuentes, C; Schellekens, H; Dinan, TG; Cryan, JF
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: Torres Fuentes, Cristina
    Resumen: © 2017 Elsevier Ltd Changes in microbial diversity and composition are increasingly associated with several disease states including obesity and behavioural disorders. Obesity-associated microbiota alter host energy harvesting, insulin resistance, inflammation, and fat deposition. Additionally, intestinal microbiota can regulate metabolism, adiposity, homoeostasis, and energy balance as well as central appetite and food reward signalling, which together have crucial roles in obesity. Moreover, some strains of bacteria and their metabolites might target the brain directly via vagal stimulation or indirectly through immune-neuroendocrine mechanisms. Therefore, the gut microbiota is becoming a target for new anti-obesity therapies. Further investigations are needed to elucidate the intricate gut-microbiota–host relationship and the potential of gut-microbiota-targeted strategies, such as dietary interventions and faecal microbiota transplantation, as promising metabolic therapies that help patients to maintain a healthy weight throughout life.
    Áreas temáticas: Hepatology Gastroenterology & hepatology Gastroenterology
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 24681253
    Direcció de correo del autor: cristina.torres@urv.cat
    Identificador del autor: 0000-0002-2917-6910
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/submittedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S2468125317301474
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Lancet Gastroenterology & Hepatology. 2 (10): 747-756
    Referencia de l'ítem segons les normes APA: Torres-Fuentes, C; Schellekens, H; Dinan, TG; Cryan, JF (2017). The microbiota–gut–brain axis in obesity. Lancet Gastroenterology & Hepatology, 2(10), 747-756. DOI: 10.1016/S2468-1253(17)30147-4
    DOI del artículo: 10.1016/S2468-1253(17)30147-4
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2017
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Gastroenterology,Gastroenterology & Hepatology,Hepatology
    Hepatology
    Gastroenterology & hepatology
    Gastroenterology
  • Documentos:

  • Cerca a google

    Search to google scholar