Articles producció científica> Ciències Mèdiques Bàsiques

Whole-lung Low Dose Irradiation for SARS-Cov2 Induced Pneumonia in the Geriatric Population: An Old Effective Treatment for a New Disease? Recommendation of the International Geriatric Radiotherapy Group

  • Datos identificativos

    Identificador: imarina:6394827
    Autores:
    Lara, Pedro C.Nguyen, Nam P.Macias-Verde, DavidBurgos-Burgos, JavierArenas, MeritxellZamagni, AliceVinh-Hung, VincentBaumert, Brigitta G.Motta, MicaelaMyint, Arthur SunBonet, MartaPopescu, TiberiuTe VuongAppalanaido, Gokula KumarTrigo, LurdesKarlsson, UlfThariat, Juliette
    Resumen:
    A cytokine storm induced by SARS-Cov2 may produce pneumonitis which may be fatal for older patients with underlying lung disease. Hyper-elevation of Interleukin1 (IL-1), Tumor necrosis factor-1alfa (TNF1 alfa), and Interleukin 6 (IL-6) produced by inflammatory macrophage M1 may damage the lung alveoli leading to severe pneumonitis, decreased oxygenation, and potential death despite artificial ventilation. Older patients may not be suitable candidates for pharmaceutical intervention targeting IL-1/6 blockade or artificial ventilation. Low dose total lung (LDTL) irradiation at a single dose of 50 cGy may stop this cytokine cascade, thus preventing, and/or reversing normal organs damage. This therapy has been proven in the past to be effective against pneumonitis of diverse etiology and could be used to prevent death of older infected patients. Thus, LDRT radiotherapy may be a cost-effective treatment for this frail patient population whom radiation - induced malignancy is not a concern because of their advanced age. This hypothesis should be tested in future prospective trials.
  • Otros:

    Autor según el artículo: Lara, Pedro C.; Nguyen, Nam P.; Macias-Verde, David; Burgos-Burgos, Javier; Arenas, Meritxell; Zamagni, Alice; Vinh-Hung, Vincent; Baumert, Brigitta G.; Motta, Micaela; Myint, Arthur Sun; Bonet, Marta; Popescu, Tiberiu; Te Vuong; Appalanaido, Gokula Kumar; Trigo, Lurdes; Karlsson, Ulf; Thariat, Juliette;
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: Arenas Prat, Meritxell
    Palabras clave: X-rays Treatment Sars-cov 2 Roentgen therapy Ldrt Inflammation Infections Historical use Elderly
    Resumen: A cytokine storm induced by SARS-Cov2 may produce pneumonitis which may be fatal for older patients with underlying lung disease. Hyper-elevation of Interleukin1 (IL-1), Tumor necrosis factor-1alfa (TNF1 alfa), and Interleukin 6 (IL-6) produced by inflammatory macrophage M1 may damage the lung alveoli leading to severe pneumonitis, decreased oxygenation, and potential death despite artificial ventilation. Older patients may not be suitable candidates for pharmaceutical intervention targeting IL-1/6 blockade or artificial ventilation. Low dose total lung (LDTL) irradiation at a single dose of 50 cGy may stop this cytokine cascade, thus preventing, and/or reversing normal organs damage. This therapy has been proven in the past to be effective against pneumonitis of diverse etiology and could be used to prevent death of older infected patients. Thus, LDRT radiotherapy may be a cost-effective treatment for this frail patient population whom radiation - induced malignancy is not a concern because of their advanced age. This hypothesis should be tested in future prospective trials.
    Áreas temáticas: Psicología Pathology and forensic medicine Neurology (clinical) Medicina ii Medicina i Interdisciplinar Geriatrics and gerontology Geriatrics & gerontology Educação física Ciências biológicas ii Cell biology
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: meritxell.arenas@urv.cat
    Identificador del autor: 0000-0003-0815-2570
    Fecha de alta del registro: 2023-02-19
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: http://www.aginganddisease.org/EN/10.14336/AD.2020.0506#1
    Referencia al articulo segun fuente origial: Aging And Disease. 11 (3): 489-493
    Referencia de l'ítem segons les normes APA: Lara, Pedro C.; Nguyen, Nam P.; Macias-Verde, David; Burgos-Burgos, Javier; Arenas, Meritxell; Zamagni, Alice; Vinh-Hung, Vincent; Baumert, Brigitta G (2020). Whole-lung Low Dose Irradiation for SARS-Cov2 Induced Pneumonia in the Geriatric Population: An Old Effective Treatment for a New Disease? Recommendation of the International Geriatric Radiotherapy Group. Aging And Disease, 11(3), 489-493. DOI: 10.14336/AD.2020.0506
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.14336/AD.2020.0506
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Cell Biology,Geriatrics & Gerontology,Geriatrics and Gerontology,Neurology (Clinical),Pathology and Forensic Medicine
    X-rays
    Treatment
    Sars-cov 2
    Roentgen therapy
    Ldrt
    Inflammation
    Infections
    Historical use
    Elderly
    Psicología
    Pathology and forensic medicine
    Neurology (clinical)
    Medicina ii
    Medicina i
    Interdisciplinar
    Geriatrics and gerontology
    Geriatrics & gerontology
    Educação física
    Ciências biológicas ii
    Cell biology
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