Autor según el artículo: Barrubés L, Babio N, Hernández-Alonso P, Toledo E, Ramírez Sabio JB, Estruch R, Ros E, Fitó M, Alonso-Gómez AM, Fiol M, Lapetra J, Serra-Majem L, Pintó X, Ruiz-Canela M, Corella D, Castañer O, Macías-González M, Salas-Salvadó J

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Babio Sánchez, Nancy Elvira / Barrubés Piñol, Laura / Salas Salvadó, Jorge

Palabras clave: Wcrf Research fund/american institute Recommendations Prevention guidelines Predimed Physical-activity questionnaire Metaanalysis Low-risk lifestyle index Lifestyle patterns Insulin Index Dietary patterns Concordance Colorectal cancer Aicr score Adherence wcrf/aicr score predimed lifestyle patterns colorectal cancer

Resumen: Limited longitudinal studies have been conducted to evaluate colorectal cancer (CRC) incidence based on the updated 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations or other global lifestyle indices, and none in aged populations at high cardiovascular risk. We aimed to assess the association between CRC incidence and adherence to two emerging lifestyles indices (2018 WCRF/AICR score and another low-risk lifestyle (LRL) score comprising smoking status, alcohol consumption, physical activity, diet, and body mass index) in the Spanish PREvencion con DIeta MEDiterranea (PREDIMED) cohort. We studied 7216 elderly men and women at high cardiovascular risk. The 2018 WCRF/AICR and LRL scores were calculated. Multivariable Cox proportional regression models were fitted to estimate the HRs (hazard ratios) and 95% confidence intervals (CIs) for incident CRC events. During a median interquartile range (IQR) follow-up of 6.0 (4.4-7.3) years, 97 CRC events were considered. A significant linear association was observed between each 1-point increment in the WCRF/AICR score (score range from 0 to 7) and CRC risk (HR (95% CI) = 0.79 (0.63-0.99)). Similarly, each 1-point increment in the LRL score (score range from 0 to 5) was associated with a 22% reduction in CRC risk (0.78 (0.64-0.96)). Adhering to emergent lifestyle scores might substantially reduce CRC incidence in elderly individuals. Further longitudinal studies, which take different lifestyle indexes into account, are warranted in the future.

Áreas temáticas: Medicine, general & internal Medicine (miscellaneous) Medicine (all)

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20770383

Direcció de correo del autor: nancy.babio@urv.cat jordi.salas@urv.cat

Identificador del autor: 0000-0003-3527-5277 0000-0003-2700-7459

Fecha de alta del registro: 2023-02-19

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/2077-0383/9/4/1215

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Journal Of Clinical Medicine. 9 (4):

Referencia de l'ítem segons les normes APA: Barrubés L, Babio N, Hernández-Alonso P, Toledo E, Ramírez Sabio JB, Estruch R, Ros E, Fitó M, Alonso-Gómez AM, Fiol M, Lapetra J, Serra-Majem L, Pint (2020). Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study. Journal Of Clinical Medicine, 9(4), -. DOI: 10.3390/jcm9041215

DOI del artículo: 10.3390/jcm9041215

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2020

Tipo de publicación: Journal Publications