Autor según el artículo: Grau-bové C; González-quilen C; Terra X; Teresa Blay M; Beltrán-Debón R; Jorba-martín R; Espina B; Pinent M; Ardévol A

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Ardèvol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / GONZALEZ QUILEN, CARLOS ALBERTO / Jorba Martin, Rosa Maria / Pinent Armengol, Montserrat / Terra Barbadora, Ximena

Palabras clave: Pyy Procyanidins Pig Metabolism Intestine Gut hormones Grape seed extract Glucagon-like peptide-1 Glp-1 Ghrelin production Flavonoids Cells Cck Bitter Absorption pyy glp-1 flavonoids cck

Resumen: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Some beneficial effects of grape seed proanthocyanidin extract (GSPE) can be explained by the modulation of enterohormone secretion. As GSPE comprises a combination of different molecules, the pure compounds that cause these effects need to be elucidated. The enterohormones and chemoreceptors present in the gastrointestinal tract differ between species, so if humans are to gain beneficial effects, species closer to humans—and humans themselves—must be used. We demonstrate that 100 mg/L of GSPE stimulates peptide YY (PYY) release, but not glucagon-like peptide 1 (GLP-1) release in the human colon. We used a pig ex vivo system that differentiates between apical and basolateral intestinal sides to analyse how apical stimulation with GSPE and its pure compounds affects the gastrointestinal tract. In pigs, apical GSPE treatment stimulates the basolateral release of PYY in the duodenum and colon and that of GLP-1 in the ascending, but not the descending colon. In the duodenum, luminal stimulation with procyanidin dimer B2 increased PYY secretion, but not CCK secretion, while catechin monomers (catechin/epicatechin) significantly increased CCK release, but not PYY release. The differential effects of GSPE and its pure compounds on enterohormone release at the same intestinal segment suggest that they act through chemosensors located apically and unevenly distributed along the gastrointestinal tract.

Áreas temáticas: Química Molecular biology Materiais General medicine Farmacia Ensino Biochemistry & molecular biology Biochemistry

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 2218273X

Direcció de correo del autor: rosamaria.jorba@urv.cat ximena.terra@urv.cat raul.beltran@urv.cat montserrat.pinent@urv.cat mteresa.blay@urv.cat anna.ardevol@urv.cat

Identificador del autor: 0000-0003-3307-4340 0000-0003-1043-5844 0000-0001-9691-1906 0000-0003-3550-5378 0000-0002-6256-9847 0000-0003-0156-7538

Fecha de alta del registro: 2023-06-17

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/2218-273X/10/6/844

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Biomolecules. 10 (6): 1-14

Referencia de l'ítem segons les normes APA: Grau-bové C; González-quilen C; Terra X; Teresa Blay M; Beltrán-Debón R; Jorba-martín R; Espina B; Pinent M; Ardévol A (2020). Effects of flavanols on enteroendocrine secretion. Biomolecules, 10(6), 1-14. DOI: 10.3390/biom10060844

DOI del artículo: 10.3390/biom10060844

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2020

Tipo de publicación: Journal Publications