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Breast-Milk Microbiota Linked to Celiac Disease Development in Children: A Pilot Study From the PreventCD Cohort

  • Datos identificativos

    Identificador: imarina:6685158
    Autores:
    Benítez-Páez AOlivares MSzajewska HPieścik-Lech MPolanco ICastillejo GNuñez MRibes-Koninckx CKorponay-Szabó IRKoletzko SMeijer CRMearin MLSanz Y
    Resumen:
    © Copyright © 2020 Benítez-Páez, Olivares, Szajewska, Pieścik-Lech, Polanco, Castillejo, Nuñez, Ribes-Koninckx, Korponay-Szabó, Koletzko, Meijer, Mearin and Sanz. Celiac disease (CeD) is an immune-mediated disorder triggered by exposure to dietary gluten proteins in genetically predisposed individuals. In addition to the host genome, the microbiome has recently been linked to CeD risk and pathogenesis. To progress in our understanding of the role of breast milk microbiota profiles in CeD, we have analyzed samples from a sub-set of mothers (n = 49) included in the PreventCD project, whose children did or did not develop CeD. The results of the microbiota data analysis indicated that neither the BMI, HLA-DQ genotype, the CeD condition nor the gluten-free diet of the mothers could explain the human milk microbiota profiles. Nevertheless, we found that origin country, the offspring’s birth date and, consequently, the milk sampling date influenced the abundance and prevalence of microbes in human milk, undergoing a transition from an anaerobic to a more aerobic microbiota, including potential pathogenic species. Furthermore, certain microbial species were more abundant in milk samples from mothers whose children went on to develop CeD compared to those that remained healthy. These included increases in facultative methylotrophs such as Methylobacterium komagatae and Methylocapsa palsarum as well as in species such as Bacteroides vulgatus, that consumes fucosylated-oligosaccharides present in human milk, and other breast-abscess associated species. Theoretically, these microbiota components could be vertically transmitted from mothers-to-infants during breastfeeding, thereby influencing CeD risk.
  • Otros:

    Autor según el artículo: Benítez-Páez A; Olivares M; Szajewska H; Pieścik-Lech M; Polanco I; Castillejo G; Nuñez M; Ribes-Koninckx C; Korponay-Szabó IR; Koletzko S; Meijer CR; Mearin ML; Sanz Y
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Castillejo De Villasante, Gemma
    Palabras clave: Risk Mothers Infants Human milk microbiota Hla genotype Contamination Children Celiac disease
    Resumen: © Copyright © 2020 Benítez-Páez, Olivares, Szajewska, Pieścik-Lech, Polanco, Castillejo, Nuñez, Ribes-Koninckx, Korponay-Szabó, Koletzko, Meijer, Mearin and Sanz. Celiac disease (CeD) is an immune-mediated disorder triggered by exposure to dietary gluten proteins in genetically predisposed individuals. In addition to the host genome, the microbiome has recently been linked to CeD risk and pathogenesis. To progress in our understanding of the role of breast milk microbiota profiles in CeD, we have analyzed samples from a sub-set of mothers (n = 49) included in the PreventCD project, whose children did or did not develop CeD. The results of the microbiota data analysis indicated that neither the BMI, HLA-DQ genotype, the CeD condition nor the gluten-free diet of the mothers could explain the human milk microbiota profiles. Nevertheless, we found that origin country, the offspring’s birth date and, consequently, the milk sampling date influenced the abundance and prevalence of microbes in human milk, undergoing a transition from an anaerobic to a more aerobic microbiota, including potential pathogenic species. Furthermore, certain microbial species were more abundant in milk samples from mothers whose children went on to develop CeD compared to those that remained healthy. These included increases in facultative methylotrophs such as Methylobacterium komagatae and Methylocapsa palsarum as well as in species such as Bacteroides vulgatus, that consumes fucosylated-oligosaccharides present in human milk, and other breast-abscess associated species. Theoretically, these microbiota components could be vertically transmitted from mothers-to-infants during breastfeeding, thereby influencing CeD risk.
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Microbiology (medical) Microbiology Medicina veterinaria Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geografía Geociências Farmacia Ensino Engenharias iii Engenharias ii Engenharias i Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: gemma.castillejo@urv.cat
    Fecha de alta del registro: 2023-02-23
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fmicb.2020.01335/full
    Referencia al articulo segun fuente origial: Frontiers In Microbiology. 11 (1335):
    Referencia de l'ítem segons les normes APA: Benítez-Páez A; Olivares M; Szajewska H; Pieścik-Lech M; Polanco I; Castillejo G; Nuñez M; Ribes-Koninckx C; Korponay-Szabó IR; Koletzko S; Meijer CR; (2020). Breast-Milk Microbiota Linked to Celiac Disease Development in Children: A Pilot Study From the PreventCD Cohort. Frontiers In Microbiology, 11(1335), -. DOI: 10.3389/fmicb.2020.01335
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.3389/fmicb.2020.01335
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Microbiology,Microbiology (Medical)
    Risk
    Mothers
    Infants
    Human milk microbiota
    Hla genotype
    Contamination
    Children
    Celiac disease
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Microbiology (medical)
    Microbiology
    Medicina veterinaria
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Interdisciplinar
    Geografía
    Geociências
    Farmacia
    Ensino
    Engenharias iii
    Engenharias ii
    Engenharias i
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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