Autor según el artículo: Astiarraga B, Martínez L, Ceperuelo-Mallafré V, Llauradó G, Terrón-Puig M, Rodríguez MM, Casajoana A, Pellitero S, Megía A, Vilarrasa N, Vendrell J, Fernández-Veledo S

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: Ceperuelo Mallafré, Maria Victoria / Domínguez Porfirio, Brenno / Fernandez Veledo, Sonia / Megía Colet, Ana / Vendrell Ortega, Juan José

Palabras clave: Itaconate Impact Beta-cell function Bariatric surgery

Resumen: To explore the meal response of circulating succinate in patients with obesity and type 2 diabetes undergoing bariatric surgery and to examine the role of gastrointestinal glucose sensing in succinate dynamics in healthy subjects.Cohort I comprised 45 patients with morbid obesity and type 2 diabetes (BMI 39.4 ± 1.9 kg/m2) undergoing metabolic surgery. Cohort II was a confirmatory cohort of 13 patients (BMI 39.3 ± 1.4 kg/m2) undergoing gastric bypass surgery. Cohort III comprised 15 healthy subjects (BMI 26.4 ± 0.5 kg/m2). Cohorts I and II completed a 2-h mixed-meal tolerance test (MTT) before the intervention and at 1 year of follow-up, and cohort II also completed a 3-h lipid test (LT). Cohort III underwent a 3-h oral glucose tolerance test (OGTT) and an isoglycemic intravenous glucose infusion (IIGI) study.In cohort I, succinate response to MTT at follow-up was greater than before the intervention (P < 0.0001). This response was confirmed in cohort II with a greater increase after 1 year of surgery (P = 0.009). By contrast, LT did not elicit a succinate response. Changes in succinate response were associated with changes in the area under the curve of glucose (r = 0.417, P < 0.0001) and insulin (r = 0.204, P = 0.002). In cohort III, glycemia, per se, stimulated a plasma succinate response (P = 0.0004), but its response was greater in the OGTT (P = 0.02; OGTT versus IIGI).The meal-related response of circulating succinate in patients with obesity and type 2 diabetes is recovered after metabolic surgery.© 2020 by the American Diabetes Association.

Áreas temáticas: Saúde coletiva Odontología Nutrição Medicina iii Medicina ii Medicina i Internal medicine Interdisciplinar General medicine Engenharias iv Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i Biotecnología Antropologia / arqueologia Advanced and specialized nursing

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 01495992

Direcció de correo del autor: brenno.dominguez@urv.cat sonia.fernandez@urv.cat victoria.ceperuelo@urv.cat juanjose.vendrell@urv.cat ana.megia@urv.cat

Identificador del autor: 0000-0003-2216-8974 0000-0003-2906-3788 0000-0002-4460-9761 0000-0002-6994-6115 0000-0002-5101-9452

Fecha de alta del registro: 2023-10-07

Versión del articulo depositado: info:eu-repo/semantics/submittedVersion

Enlace a la fuente original: https://care.diabetesjournals.org/content/43/10/2581

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Diabetes Care. 43 (10): 2581-2587

Referencia de l'ítem segons les normes APA: Astiarraga B, Martínez L, Ceperuelo-Mallafré V, Llauradó G, Terrón-Puig M, Rodríguez MM, Casajoana A, Pellitero S, Megía A, Vilarrasa N, Vendrell J, F (2020). Impaired Succinate Response to a Mixed Meal in Obesity and Type 2 Diabetes Is Normalized After Metabolic Surgery. Diabetes Care, 43(10), 2581-2587. DOI: 10.2337/dc20-0460

DOI del artículo: 10.2337/dc20-0460

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2020

Tipo de publicación: Journal Publications