Articles producció científica> Medicina i Cirurgia

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

  • Datos identificativos

    Identificador: imarina:9002835
    Autores:
    Vogelezang SBradfield JPAhluwalia TSCurtin JALakka TAGrarup NScholz Mvan der Most PJMonnereau CStergiakouli EHeiskala AHorikoshi MFedko IOVilor-Tejedor NCousminer DLStandl MWang CAViikari JGeller FÍñiguez CPitkänen NChesi ABacelis JYengo LTorrent MNtalla IHelgeland ØSelzam SVonk JMZafarmand MHHeude BFarooqi ISAlyass ABeaumont RNHave CTRzehak PBilbao JRSchnurr TMBarroso IBønnelykke K
    Resumen:
    © 2020 Public Library of Science. All rights reserved. The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.
  • Otros:

    Autor según el artículo: Vogelezang S; Bradfield JP; Ahluwalia TS; Curtin JA; Lakka TA; Grarup N; Scholz M; van der Most PJ; Monnereau C; Stergiakouli E; Heiskala A; Horikoshi M; Fedko IO; Vilor-Tejedor N; Cousminer DL; Standl M; Wang CA; Viikari J; Geller F; Íñiguez C; Pitkänen N; Chesi A; Bacelis J; Yengo L; Torrent M; Ntalla I; Helgeland Ø; Selzam S; Vonk JM; Zafarmand MH; Heude B; Farooqi IS; Alyass A; Beaumont RN; Have CT; Rzehak P; Bilbao JR; Schnurr TM; Barroso I; Bønnelykke K
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Closa Monasterolo, Ricardo / Escribano Subías, Joaquín
    Palabras clave: Young-adults Prostate-specific antigen Pooled analysis Overweight Obesity Mendelian randomization Genome-wide association Genetic-variation Cardiovascular risk Adiposity
    Resumen: © 2020 Public Library of Science. All rights reserved. The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Molecular biology Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Geociências Genetics (clinical) Genetics & heredity Genetics Filosofia/teologia:subcomissão filosofia Farmacia Engenharias iv Educação física Ecology, evolution, behavior and systematics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência da computação Cancer research Biotecnología Biodiversidade Astronomia / física Antropologia / arqueologia
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: joaquin.escribano@urv.cat ricardo.closa@urv.cat
    Identificador del autor: 0000-0002-5041-459X 0000-0002-9963-4163
    Fecha de alta del registro: 2023-02-19
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008718
    Referencia al articulo segun fuente origial: Plos Genetics. 16 (10): e1008718-
    Referencia de l'ítem segons les normes APA: Vogelezang S; Bradfield JP; Ahluwalia TS; Curtin JA; Lakka TA; Grarup N; Scholz M; van der Most PJ; Monnereau C; Stergiakouli E; Heiskala A; Horikoshi (2020). Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. Plos Genetics, 16(10), e1008718-. DOI: 10.1371/journal.pgen.1008718
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1371/journal.pgen.1008718
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Cancer Research,Ecology, Evolution, Behavior and Systematics,Genetics,Genetics & Heredity,Genetics (Clinical),Molecular Biology
    Young-adults
    Prostate-specific antigen
    Pooled analysis
    Overweight
    Obesity
    Mendelian randomization
    Genome-wide association
    Genetic-variation
    Cardiovascular risk
    Adiposity
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Molecular biology
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Geociências
    Genetics (clinical)
    Genetics & heredity
    Genetics
    Filosofia/teologia:subcomissão filosofia
    Farmacia
    Engenharias iv
    Educação física
    Ecology, evolution, behavior and systematics
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência da computação
    Cancer research
    Biotecnología
    Biodiversidade
    Astronomia / física
    Antropologia / arqueologia
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