Autor según el artículo: Papandreou C; Hernández-Alonso P; Bulló M; Ruiz-Canela M; Li J; Guasch-Ferré M; Toledo E; Clish C; Corella D; Estruch R; Cofán M; Fitó M; Razquin C; Arós F; Fiol M; Santos-Lozano JM; Serra-Majem L; Liang L; Martínez-González MA; Hu FB; Salas-Salvadó J

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Bulló Bonet, Mònica / Salas Salvadó, Jorge

Palabras clave: Predimed Heart failure Glutamine Glutamate Atrial fibrillation

Resumen: © 2020 The Author(s). Published by Oxford University Press on behalf of the American Society for Nutrition. Background: Although the association between glutamate and glutamine in relation to cardiometabolic disorders has been evaluated, the role of these metabolites in the development of atrial fibrillation (AF) and heart failure (HF) remains unknown. Objectives: We examined associations of glutamate, glutamine, and the glutamine-to-glutamate ratio with AF and HF incidence in a Mediterranean population at high cardiovascular disease (CVD) risk. Methods: The present study used 2 nested case-control studies within the PREDIMED (Prevención con Dieta Mediterránea) study. During ∼10 y of follow-up, there were 509 AF incident cases matched to 618 controls and 326 HF incident cases matched to 426 controls. Plasma concentrations of glutamate and glutamine were semiquantitatively profiled with LC-tandem MS. ORs were estimated with multivariable conditional logistic regression models. Results: In fully adjusted models, per 1-SD increment, glutamate was associated with a 29% (95% CI: 1.08, 1.54) increased risk of HF and glutamine-to-glutamate ratio with a 20% (95% CI: 0.67, 0.94) decreased risk. Glutamine-to-glutamate ratio was also inversely associated with HF risk (OR per 1-SD increment: 0.80; 95% CI: 0.67, 0.94) when comparing extreme quartiles. Higher glutamate concentrations were associated with a worse cardiometabolic risk profile, whereas a higher glutamine-to-glutamate ratio was associated with a better cardiometabolic risk profile. No associations between the concentrations of these metabolites and AF were observed. Conclusions: Our findings suggest that high plasma glutamate concentrations possibly resulting from alterations in the glutamate-glutamine cycle may contribute to the development of HF in Mediterranean individuals at high CVD risk. This trial was registered at www.isrctn.com as ISRCTN35739639.

Áreas temáticas: Serviço social Saúde coletiva Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ensino Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: jordi.salas@urv.cat monica.bullo@urv.cat

Identificador del autor: 0000-0003-2700-7459 0000-0002-0218-7046

Fecha de alta del registro: 2023-02-19

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://academic.oup.com/jn/article/150/11/2882/5906638

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Journal Of Nutrition. 150 (11): 2882-2889

Referencia de l'ítem segons les normes APA: Papandreou C; Hernández-Alonso P; Bulló M; Ruiz-Canela M; Li J; Guasch-Ferré M; Toledo E; Clish C; Corella D; Estruch R; Cofán M; Fitó M; Razquin C; A (2020). High plasma glutamate and a low glutamine-to-glutamate ratio are associated with increased risk of heart Failure but Not Atrial Fibrillation in the Prevención con Dieta Mediterránea (PREDIMED) Study. Journal Of Nutrition, 150(11), 2882-2889. DOI: 10.1093/jn/nxaa273

DOI del artículo: 10.1093/jn/nxaa273

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2020

Tipo de publicación: Journal Publications