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DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

  • Datos identificativos

    Identificador: imarina:9138911
    Handle: https://hdl.handle.net/20.500.11797/imarina9138911
    Autores:
    Vehmeijer FOLKüpers LKSharp GCSalas LALent SJima DDTindula GReese SQi CGruzieva OPage CRezwan FIMelton PENohr EEscaramís GRzehak PHeiskala AGong TTuominen STGao LRoss JPStarling APHolloway JWYousefi PAasvang GMBeilin LJBergström ABinder EChatzi LCorpeleijn ECzamara DEskenazi BEwart SFerre NGrote VGruszfeld DHåberg SEHoyo CHuen KKarlsson R
    Resumen:
    © 2020, The Author(s). Background: DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods: We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results: DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × 10−7, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously ide

  • Otros:

    Autor según el artículo: Vehmeijer FOL; Küpers LK; Sharp GC; Salas LA; Lent S; Jima DD; Tindula G; Reese S; Qi C; Gruzieva O; Page C; Rezwan FI; Melton PE; Nohr E; Escaramís G; Rzehak P; Heiskala A; Gong T; Tuominen ST; Gao L; Ross JP; Starling AP; Holloway JW; Yousefi P; Aasvang GM; Beilin LJ; Bergström A; Binder E; Chatzi L; Corpeleijn E; Czamara D; Eskenazi B; Ewart S; Ferre N; Grote V; Gruszfeld D; Håberg SE; Hoyo C; Huen K; Karlsson R
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Ferre Pallas, Natalia
    Palabras clave: Epigenetics Dna methylation Cord blood Childhood obesity Body mass index promoter methylation obesity loci lms method epigenetics dna methylation discovery children childhood obesity childhood bmi adiposity
    Resumen: © 2020, The Author(s). Background: DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods: We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results: DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × 10−7, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × 10−4; adolescence Penrichment = 2.10 × 10−7). Conclusions: There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. These findings may be compatible with the hypothesis that DNA methylation differences are mostly a consequence rather than a cause of obesity.
    Áreas temáticas: Saúde coletiva Molecular medicine Molecular biology Medicina ii Medicina i Genetics (clinical) Genetics & heredity Genetics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: natalia.ferre@urv.cat
    Identificador del autor: 0000-0002-2838-1525
    Fecha de alta del registro: 2023-02-19
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-020-00810-w
    Referencia al articulo segun fuente origial: Genome Medicine. 12 (1):
    Referencia de l'ítem segons les normes APA: Vehmeijer FOL; Küpers LK; Sharp GC; Salas LA; Lent S; Jima DD; Tindula G; Reese S; Qi C; Gruzieva O; Page C; Rezwan FI; Melton PE; Nohr E; Escaramís G (2020). DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies. Genome Medicine, 12(1), -. DOI: 10.1186/s13073-020-00810-w
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1186/s13073-020-00810-w
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Tipo de publicación: Journal Publications

  • Palabras clave:

    Genetics,Genetics & Heredity,Genetics (Clinical),Molecular Biology,Molecular Medicine
    Epigenetics
    Dna methylation
    Cord blood
    Childhood obesity
    Body mass index
    promoter methylation
    obesity
    loci
    lms method
    epigenetics
    dna methylation
    discovery
    children
    childhood obesity
    childhood
    bmi
    adiposity
    Saúde coletiva
    Molecular medicine
    Molecular biology
    Medicina ii
    Medicina i
    Genetics (clinical)
    Genetics & heredity
    Genetics
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i

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