Autor según el artículo: Grau-Bove, Carme; Sierra-Cruz, Marta; Miguens-Gomez, Alba; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Blay, Mayte; Terra, Ximena; Pinent, Montserrat; Ardevol, Anna
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Grau Bové, Maria Carmen / Miguéns Gómez, Alba / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Sierra Cruz, Marta / Terra Barbadora, Ximena
Palabras clave: Tumor Time factors Rats, wistar Rats Procyanidins Proanthocyanidins Grape seed proanthocyanidins Grape seed extract Glucagon/insulin Food intake Female Drug administration schedule Body weight Body composition Animals Aging Ageing Adiposity
Resumen: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Adaptive homeostasis declines with age and this leads to, among other things, the appearance of chronic age-related pathologies such as cancer, neurodegeneration, osteoporosis, sarcopenia, cardiovascular disease and diabetes. Grape seed-derived procyanidins (GSPE) have been shown to be effective against several of these pathologies, mainly in young animal models. Here we test their effectiveness in aged animals: 21-month-old female rats were treated with 500 mg GSPE/kg of body weight for ten days. Afterwards they were kept on a chow diet for eleven weeks. Food intake, body weight, metabolic plasma parameters and tumor incidence were measured. The GSPE administered to aged rats had an effect on food intake during the treatment and after eleven weeks continued to have an effect on visceral adiposity. It prevented pancreas dysfunction induced by ageing and maintained a higher glucagon/insulin ratio together with a lower decrease in ketonemia. It was very effective in preventing age-related tumor development. All in all, this study supports the positive effect of GSPE on preventing some age-related pathologies.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: alba.miguens@urv.cat alba.miguens@urv.cat alba.miguens@urv.cat marta.sierra@estudiants.urv.cat marta.sierra@estudiants.urv.cat mariacarmen.grau@urv.cat mariacarmen.grau@urv.cat mariacarmen.grau@urv.cat anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat esther.rodriguez@urv.cat montserrat.pinent@urv.cat raul.beltran@urv.cat
Identificador del autor: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0001-9691-1906
Fecha de alta del registro: 2024-10-19
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2072-6643/12/12/3647
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Nutrients. 12 (12): 1-12
Referencia de l'ítem segons les normes APA: Grau-Bove, Carme; Sierra-Cruz, Marta; Miguens-Gomez, Alba; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Blay, Mayte; Terra, Ximena; Pinent, Montser (2020). A ten-day grape seed procyanidin treatment prevents certain ageing processes in female rats over the long term. Nutrients, 12(12), 1-12. DOI: 10.3390/nu12123647
DOI del artículo: 10.3390/nu12123647
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2020
Tipo de publicación: Journal Publications
Repositori URV