Autor según el artículo: Baiges-Gaya G; Fernández-Arroyo S; Luciano-Mateo F; Cabré N; Rodríguez-Tomàs E; Hernández-Aguilera A; Castañé H; Romeu M; Nogués MR; Camps J; Joven J

Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques

Autor/es de la URV: Baiges Gaya, Gerard

Palabras clave: Sucrose Obesity Nash Nafld Autophagy Adipose tissue

Resumen: © 2020 Elsevier Ltd Background: Obesity is a chronic progressive disease with several metabolic alterations. Nonalcoholic fatty liver disease (NAFLD) is an important comorbidity of obesity that can progress to nonalcoholic steatohepatitis (NASH), cirrhosis or hepatocarcinoma. This study aimed at clarifying the molecular mechanisms underlying the metabolic alterations in hepatic and adipose tissue during high-fat high-sucrose diet-induced NAFLD development in mice. Methods: Twenty-four male mice (C57BL/6J) were randomly allocated into 3 groups (n = 8 mice per group) to receive a chow diet, a high-fat diet (HFD), or a high-fat high-sucrose diet (HF-HSD) for 20 weeks. At sacrifice, liver and adipose tissue were obtained for histopathological, metabolomic, and protein expression analyses. Results: HF-HSD (but not HFD) was associated with NASH and increased oxidative stress. These animals presented an inhibition of hepatic autophagy and alterations in AMP-activated protein kinase/mammalian target of rapamycin activity. We also observed that the ability of metabolic adaptation was adversely affected by the increase of damaged mitochondria. NASH development was associated with changes in adipose tissue dynamics and increased amounts of saturated fatty acids, monounsaturated fatty acids and polyunsaturated fatty acids in visceral adipose tissue. Conclusion: HF-HSD led to a metabolic blockage and impaired hepatic mitochondria turnover. In addition, the continuous accumulation of fatty acids produced adipose tissue dysfunction and hepatic fat accumulation that favored the progression to NASH.

Áreas temáticas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Molecular biology Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Enfermagem Endocrinology, diabetes and metabolism Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biochemistry & molecular biology Biochemistry

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Identificador del autor: 0000-0003-4626-5672 0000-0002-2131-1858 0000-0003-2749-4541

Direcció de correo del autor: gerard.baiges@estudiants.urv.cat

Fecha de alta del registro: 2022-07-24

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S095528632030591X?via%3Dihub#!

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Journal Of Nutritional Biochemistry. 89 108559-

Referencia de l'ítem segons les normes APA: Baiges-Gaya G; Fernández-Arroyo S; Luciano-Mateo F; Cabré N; Rodríguez-Tomàs E; Hernández-Aguilera A; Castañé H; Romeu M; Nogués MR; Camps J; Joven J (2021). Hepatic metabolic adaptation and adipose tissue expansion are altered in mice with steatohepatitis induced by high-fat high sucrose diet. Journal Of Nutritional Biochemistry, 89(), 108559-. DOI: 10.1016/j.jnutbio.2020.108559

DOI del artículo: 10.1016/j.jnutbio.2020.108559

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2021

Tipo de publicación: Journal Publications