Autor según el artículo: Castro-Barquero, Sara; Ribo-Coll, Margarita; Lassale, Camille; Tresserra-Rimbau, Anna; Castaner, Olga; Pinto, Xavier; Angel Martinez-Gonzalez, Miguel; Sorli, Jose, V; Salas-Salvado, Jordi; Lapetra, Jose; Gomez-Gracia, Enrique; Alonso-Gomez, Angel M; Fiol, Miquel; Serra-Majem, Lluis; Sacanella, Emilio; Javier Basterra-Gortari, Francisco; Portoles, Olga; Babio, Nancy; Cofan, Montserrat; Ros, Emilio; Estruch, Ramon; Hernaez, Alvaro
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Babio Sánchez, Nancy Elvira / Salas Salvadó, Jorge
Palabras clave: Vitamin k epoxide reductases Time factors Randomized controlled trials Prevention Platelet aggregation inhibitors Olive oil Nuts Middle aged Mediterranean diet Male Humans Heart disease risk factors Fibrinolytic agents Female Enzyme inhibitors Diet, mediterranean Diet, fat-restricted Cardiovascular diseases Aged 4-hydroxycoumarins
Resumen: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Our aim is to assess whether following a Mediterranean Diet (MedDiet) decreases the risk of initiating antithrombotic therapies and the cardiovascular risk associated with its use in older individuals at high cardiovascular risk. We evaluate whether participants of the PREvención con DIeta MEDiterránea (PREDIMED) study allocated to a MedDiet enriched in extra-virgin olive oil or nuts (versus a low-fat control intervention) disclose differences in the risk of initiation of: (1) vitamin K epoxide reductase inhibitors (acenocumarol/warfarin; n = 6772); (2) acetylsalicylic acid as antiplatelet agent (n = 5662); and (3) other antiplatelet drugs (cilostazol/clopidogrel/dipyridamole/ditazol/ticlopidine/triflusal; n = 6768). We also assess whether MedDiet modifies the association between the antithrombotic drug baseline use and incident cardiovascular events. The MedDiet intervention enriched with extra-virgin olive oil decreased the risk of initiating the use of vitamin K epoxide reductase inhibitors relative to control diet (HR: 0.68 [0.46–0.998]). Their use was also more strongly associated with an increased risk of cardiovascular disease in participants not allocated to MedDiet interventions (HRcontrol diet: 4.22 [1.92–9.30], HRMedDiets: 1.71 [0.83–3.52], p-interaction = 0.052). In conclusion, in an older population at high cardiovascular risk, following a MedDiet decreases the initiation of antithrombotic therapies and the risk of suffering major cardiovascular events among users of vitamin K epoxide reductase inhibitors.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: jordi.salas@urv.cat nancy.babio@urv.cat
Identificador del autor: 0000-0003-2700-7459 0000-0003-3527-5277
Fecha de alta del registro: 2025-02-19
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Nutrients. 12 (12): 1-14
Referencia de l'ítem segons les normes APA: Castro-Barquero, Sara; Ribo-Coll, Margarita; Lassale, Camille; Tresserra-Rimbau, Anna; Castaner, Olga; Pinto, Xavier; Angel Martinez-Gonzalez, Miguel; (2020). Mediterranean diet decreases the initiation of use of vitamin k epoxide reductase inhibitors and their associated cardiovascular risk: A randomized controlled trial. Nutrients, 12(12), 1-14. DOI: 10.3390/nu12123895
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2020
Tipo de publicación: Journal Publications
Repositori URV