Autor según el artículo: Cabré N; Gil M; Amigó N; Luciano-Mateo F; Baiges-Gaya G; Fernández-Arroyo S; Rodríguez-Tomàs E; Hernández-Aguilera A; Castañé H; París M; Sabench F; Del Castillo D; Camps J; Joven J
Departamento: Medicina i Cirurgia
e-ISSN: 2045-2322
Autor/es de la URV: Del Castillo Déjardin, Daniel / FERNANDEZ ARROYO, SALVADOR / Joven Maried, Jorge / Sabench Pereferrer, Fàtima
Resumen: © 2021, The Author(s). Patients with morbid obesity frequently present non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) associated with pro-atherogenic alterations. Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for weight reduction, and for the remission of hepatic alterations. Using 1H-nuclear magnetic resonance (1H-NMR), we investigated the effects of LSG on lipoprotein and glycoprotein profile in patients with morbid obesity and liver disease. We included 154 patients with morbid obesity (49 non-NASH, 54 uncertain NASH, 51 definite NASH). A blood sample was obtained before surgery and, in patients with definite NASH, one year after surgery. Patients with NASH had increased concentrations of medium and small VLDL particles, VLDL and IDL cholesterol concentrations, IDL, LDL, and HDL triglyceride concentrations, and elevated glycoprotein levels. These changes were more marked in patients with type 2 diabetes mellitus. LSG produced significant decreases in the concentration of VLDL particles, VLDL cholesterol and triglycerides, an increase in the concentration LDL particles and LDL cholesterol concentrations, and a decrease in protein glycation. We conclude that patients with obesity and NASH had significant alterations in circulating levels of lipoproteins and glycoproteins that were associated with the severity of the disease. Most of these changes were reversed post-LSG.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: danieldel.castillo@urv.cat jorge.joven@urv.cat fatima.sabench@urv.cat
Identificador del autor: 0000-0003-0456-3102 0000-0001-7024-7824 0000-0003-2749-4541 0000-0002-9262-8756
Fecha de alta del registro: 2024-07-27
Volumen de revista: 11
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.nature.com/articles/s41598-020-79485-7
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Scientific Reports. 11 (1): 1343-
Referencia de l'ítem segons les normes APA: Cabré N; Gil M; Amigó N; Luciano-Mateo F; Baiges-Gaya G; Fernández-Arroyo S; Rodríguez-Tomàs E; Hernández-Aguilera A; Castañé H; París M; Sabench F; D (2021). Laparoscopic sleeve gastrectomy alters 1H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease. Scientific Reports, 11(1), 1343-. DOI: 10.1038/s41598-020-79485-7
DOI del artículo: 10.1038/s41598-020-79485-7
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications