Articles producció científica> Medicina i Cirurgia

Laparoscopic sleeve gastrectomy alters 1H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease

  • Datos identificativos

    Identificador: imarina:9149607
    Autores:
    Cabré NGil MAmigó NLuciano-Mateo FBaiges-Gaya GFernández-Arroyo SRodríguez-Tomàs EHernández-Aguilera ACastañé HParís MSabench FDel Castillo DCamps JJoven J
    Resumen:
    © 2021, The Author(s). Patients with morbid obesity frequently present non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) associated with pro-atherogenic alterations. Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for weight reduction, and for the remission of hepatic alterations. Using 1H-nuclear magnetic resonance (1H-NMR), we investigated the effects of LSG on lipoprotein and glycoprotein profile in patients with morbid obesity and liver disease. We included 154 patients with morbid obesity (49 non-NASH, 54 uncertain NASH, 51 definite NASH). A blood sample was obtained before surgery and, in patients with definite NASH, one year after surgery. Patients with NASH had increased concentrations of medium and small VLDL particles, VLDL and IDL cholesterol concentrations, IDL, LDL, and HDL triglyceride concentrations, and elevated glycoprotein levels. These changes were more marked in patients with type 2 diabetes mellitus. LSG produced significant decreases in the concentration of VLDL particles, VLDL cholesterol and triglycerides, an increase in the concentration LDL particles and LDL cholesterol concentrations, and a decrease in protein glycation. We conclude that patients with obesity and NASH had significant alterations in circulating levels of lipoproteins and glycoproteins that were associated with the severity of the disease. Most of these changes were reversed post-LSG.
  • Otros:

    Autor según el artículo: Cabré N; Gil M; Amigó N; Luciano-Mateo F; Baiges-Gaya G; Fernández-Arroyo S; Rodríguez-Tomàs E; Hernández-Aguilera A; Castañé H; París M; Sabench F; Del Castillo D; Camps J; Joven J
    Departamento: Medicina i Cirurgia
    e-ISSN: 2045-2322
    Autor/es de la URV: Baiges Gaya, Gerard / Camps Andreu, Jorge / CAMPS RATERA, JOSEP / Castañé Vilafranca, Helena / Del Castillo Déjardin, Daniel / FERNANDEZ ARROYO, SALVADOR / GIL TEIXIDÓ, M. DEL MAR / Joven Maried, Jorge / París Sans, Marta / Rodriguez Tomas, Elisabet / Sabench Pereferrer, Fàtima
    Palabras clave: Good health and well-being
    Resumen: © 2021, The Author(s). Patients with morbid obesity frequently present non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) associated with pro-atherogenic alterations. Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for weight reduction, and for the remission of hepatic alterations. Using 1H-nuclear magnetic resonance (1H-NMR), we investigated the effects of LSG on lipoprotein and glycoprotein profile in patients with morbid obesity and liver disease. We included 154 patients with morbid obesity (49 non-NASH, 54 uncertain NASH, 51 definite NASH). A blood sample was obtained before surgery and, in patients with definite NASH, one year after surgery. Patients with NASH had increased concentrations of medium and small VLDL particles, VLDL and IDL cholesterol concentrations, IDL, LDL, and HDL triglyceride concentrations, and elevated glycoprotein levels. These changes were more marked in patients with type 2 diabetes mellitus. LSG produced significant decreases in the concentration of VLDL particles, VLDL cholesterol and triglycerides, an increase in the concentration LDL particles and LDL cholesterol concentrations, and a decrease in protein glycation. We conclude that patients with obesity and NASH had significant alterations in circulating levels of lipoproteins and glycoproteins that were associated with the severity of the disease. Most of these changes were reversed post-LSG.
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: marta.paris@urv.cat jorge.camps@urv.cat danieldel.castillo@urv.cat helena.castane@estudiants.urv.cat gerard.baiges@estudiants.urv.cat elisabet.rodriguezt@estudiants.urv.cat elisabet.rodriguezt@estudiants.urv.cat jorge.joven@urv.cat fatima.sabench@urv.cat
    Identificador del autor: 0000-0002-3165-3640 0000-0003-0456-3102 0000-0001-7024-7824 0000-0003-2749-4541 0000-0002-9262-8756
    Fecha de alta del registro: 2024-11-23
    Volumen de revista: 11
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.nature.com/articles/s41598-020-79485-7
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Scientific Reports. 11 (1): 1343-
    Referencia de l'ítem segons les normes APA: Cabré N; Gil M; Amigó N; Luciano-Mateo F; Baiges-Gaya G; Fernández-Arroyo S; Rodríguez-Tomàs E; Hernández-Aguilera A; Castañé H; París M; Sabench F; D (2021). Laparoscopic sleeve gastrectomy alters 1H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease. Scientific Reports, 11(1), 1343-. DOI: 10.1038/s41598-020-79485-7
    DOI del artículo: 10.1038/s41598-020-79485-7
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Multidisciplinary,Multidisciplinary Sciences
    Good health and well-being
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Multidisciplinary sciences
    Multidisciplinary
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Letras / linguística
    Interdisciplinar
    Geografía
    Geociências
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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