Autor según el artículo: Lopez-Fernandez-Sobrino, Raul; Soliz-Rueda, Jorge R; Margalef, Maria; Arola-Arnal, Anna; Suarez, Manuel; Bravo, Francisca, I; Muguerza, Begona
Departamento: Bioquímica i Biotecnologia
e-ISSN: 2072-6643
Autor/es de la URV: Alkhoury, Nadine / Arola Arnal, Anna / Bravo Vázquez, Francisca Isabel / MARGALEF JORNET, MARIA / Muguerza Marquínez, Maria Begoña / Soliz Rueda, Jorge Ricardo / Suárez Recio, Manuel
Palabras clave: Winery by-product; Wine; Vitis; Shr; Rats, inbred wky; Rats, inbred shr; Rats; Polyphenols; Male; Hypertension; Captopril; Cabernet grape variety; Blood pressure; Antihypertensive agents; Animals; Angiotensin-converting enzyme inhibitors
Resumen: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Wine lees (WL) are by-products generated in the winemaking process. The aim of this study was to investigate the angiotensin-converting enzyme inhibitory (ACEi) activity, and the blood pressure (BP) lowering effect of WL from individual grape varieties. The relationship among their activities and phenolic profiles was also studied. Three WL, from Cabernet, Mazuela, and Garnacha grape varieties, were firstly selected based on their ACEi properties. Their phenolic profiles were fully characterized by UHPLC-ESI-Q-TOF-MS. Then, their potential antihypertensive effects were evaluated in spontaneously hypertensive rats (SHR). BP was recorded before and after their oral administrations (2, 4, 6, 8, 24, and 48 h) at a dose of 5 mL/kg bw. Cabernet WL (CWL) exhibited a potent antihypertensive activity, similar to that obtained with the drug Captopril. This BP-lowering effect was related to the high amount of anthocyanins and flavanols present in these lees. In addition, a potential hypotensive effect of CWL was discarded in normotensive Wistar– Kyoto rats. Finally, the ACEi and antihypertensive activities of CWL coming from a different harvest were confirmed. Our results suggest the potential of CWL for controlling arterial BP, opening the door to commercial use within the wine industry.
Áreas temáticas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Planejamento urbano e regional / demografia; Nutrition and dietetics; Nutrition & dietetics; Nutrição; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Food science; Farmacia; Engenharias iv; Engenharias ii; Enfermagem; Educação física; Economia; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: nadine.alkhoury@estudiants.urv.cat; nadine.alkhoury@estudiants.urv.cat; nadine.alkhoury@estudiants.urv.cat; nadine.alkhoury@estudiants.urv.cat; jorgericardo.soliz@urv.cat; manuel.suarez@urv.cat; franciscaisabel.bravo@urv.cat; anna.arola@urv.cat; begona.muguerza@urv.cat
Fecha de alta del registro: 2025-01-28
Volumen de revista: 13
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2072-6643/13/2/679
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Nutrients. 13 (2): 1-17
Referencia de l'ítem segons les normes APA: Lopez-Fernandez-Sobrino, Raul; Soliz-Rueda, Jorge R; Margalef, Maria; Arola-Arnal, Anna; Suarez, Manuel; Bravo, Francisca, I; Muguerza, Begona (2021). Ace inhibitory and antihypertensive activities of wine lees and relationship among bioactivity and phenolic profile. Nutrients, 13(2), 1-17. DOI: 10.3390/nu13020679
DOI del artículo: 10.3390/nu13020679
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV