Autor según el artículo: Atzeni, Alessandro; Galie, Serena; Muralidharan, Jananee; Babio, Nancy; Tinahones, Francisco Jose; Vioque, Jesus; Corella, Dolores; Castaner, Olga; Vidal, Josep; Moreno-Indias, Isabel; Torres-Collado, Laura; Fernandez-Carrion, Rebeca; Fito, Montserrat; Olbeyra, Romina; Martinez-Gonzalez, Miguel Angel; Bullo, Monica; Salas-Salvado, Jordi;

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Atzeni, Alessandro / Babio Sánchez, Nancy Elvira / Bulló Bonet, Mònica / Galiè, Serena / Muralidharan, Jananee / Salas Salvadó, Jorge

Palabras clave: Weight loss Obesity Gut microbiota Clinical trial Bmi 16s sequencing

Resumen: Gut microbiota is essential for the development of obesity and related comorbidities. However, studies describing the association between specific bacteria and obesity or weight loss reported discordant results. The present observational study, conducted within the frame of the PREDIMED-Plus clinical trial, aims to assess the association between fecal microbiota, body composition and weight loss, in response to a 12-month lifestyle intervention in a subsample of 372 individuals (age 55-75) with overweight/obesity and metabolic syndrome. Participants were stratified by tertiles of baseline body mass index (BMI) and changes in body weight after 12-month intervention. General assessments, anthropometry and biochemical measurements, and stool samples were collected. 16S amplicon sequencing was performed on bacterial DNA extracted from stool samples and microbiota analyzed. Differential abundance analysis showed an enrichment of Prevotella 9, Lachnospiraceae UCG-001 and Bacteroides, associated with a higher weight loss after 12-month of follow-up, whereas in the cross-sectional analysis, Prevotella 2 and Bacteroides were enriched in the lowest tertile of baseline BMI. Our findings suggest that fecal microbiota plays an important role in the control of body weight, supporting specific genera as potential target in personalized nutrition for obesity management. A more in-depth taxonomic identification method and the need of metabolic information encourages to further investigation.

Áreas temáticas: Virology Microbiology (medical) Microbiology

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: alessandro.atzeni@urv.cat nancy.babio@urv.cat jordi.salas@urv.cat monica.bullo@urv.cat alessandro.atzeni@urv.cat

Identificador del autor: 0000-0002-1804-8606 0000-0003-3527-5277 0000-0003-2700-7459 0000-0002-0218-7046 0000-0002-1804-8606

Fecha de alta del registro: 2023-02-26

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/2076-2607/9/2/346

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Microorganisms. 9 (2): 1-13

Referencia de l'ítem segons les normes APA: Atzeni, Alessandro; Galie, Serena; Muralidharan, Jananee; Babio, Nancy; Tinahones, Francisco Jose; Vioque, Jesus; Corella, Dolores; Castaner, Olga; Vi (2021). Gut Microbiota Profile and Changes in Body Weight in Elderly Subjects with Overweight/Obesity and Metabolic Syndrome. Microorganisms, 9(2), 1-13. DOI: 10.3390/microorganisms9020346

DOI del artículo: 10.3390/microorganisms9020346

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2021

Tipo de publicación: Journal Publications