Autor según el artículo: Sandoval-Ramírez BA; Catalán Ú; Pedret A; Valls RM; Motilva MJ; Rubió L; Solà R
Departamento: Medicina i Cirurgia
Autor/es de la URV: Catalán Santos, Úrsula / Pedret Figuerola, Anna / SANDOVAL RAMÍREZ, BERNER ANDRÉE / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
Palabras clave: Resveratrol Polyphenols Phenolic compounds Microbiota Intestinal Integrity Inflammation Health Gut Epithelial tight junctions Dysfunction Disruption Critical illness Capacity Barrier Apoptosis
Resumen: Background & aims: The integrity of the intestinal barrier in the diseased is key to prevent further complications and disease such as sepsis and death, whereas, the role of food bioactive molecules (i. e. phenolic compounds (PCs) on the intestinal barrier, is still unknown. The current aim was to explore the benefits of the oral PC administration on the intestinal barrier integrity in animals. Methods: The effects of PCs on the intestinal barrier integrity in in vivo animal models of intestinal inflammation were assessed up-to August 2020 from the PubMed, SCOPUS, and Cochrane Library databases under the PRISMA methodology. The risk of bias was assessed from ARRAY and SCYRCLE tools. Results: From 1241 articles, 14 studies were included. In animals, oral resveratrol (n = 6) improves the intestinal barrier integrity and reduces intestinal damage. Additionally, grape seed extract (n = 2), curcumin (n = 1), genistein (n = 1), chlorogenic acid (n = 1), grape pomace (n = 1), olive leaf (n = 1) or cranberry extract (n = 1) improve the intestinal barrier integrity downregulating various inflammatory molecules (TNF-α, and other interleukins), and increasing the antioxidant enzymes in animals. Furthermore, resveratrol, quercetin, epigallocatechin, and other PCs improve the epithelial barrier integrity and pro-inflammatory molecule expression in the intestinal epithelia. Conclusions: The oral PC administration in animals improves the intestinal barrier integrity and function from three main mechanisms: 1) The reduction of pro-inflammatory molecules, 2) the improvement in tight-junction protein expression, and 3) the improvement of the antioxidant intracellular activity suggesting the potential use of PCs in the management of intestinal injury in humans, particularly for resveratrol, the most studied PC.
Áreas temáticas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: ursula.catalan@urv.cat anna.pedret@urv.cat rosamaria.valls@urv.cat rosa.sola@urv.cat
Identificador del autor: 0000-0001-8884-9823 0000-0002-5327-932X 0000-0002-3351-0942 0000-0002-8359-235X
Fecha de alta del registro: 2024-07-27
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Clinical Nutrition. 40 (4): 1719-1732
Referencia de l'ítem segons les normes APA: Sandoval-Ramírez BA; Catalán Ú; Pedret A; Valls RM; Motilva MJ; Rubió L; Solà R (2021). Exploring the effects of phenolic compounds to reduce intestinal damage and improve the intestinal barrier integrity: A systematic review of in vivo animal studies. Clinical Nutrition, 40(4), 1719-1732. DOI: 10.1016/j.clnu.2020.09.027
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV