Autor según el artículo: Harms, Karen; Milic, Andrea; Stchigel, Alberto M.; Stadler, Marc; Surup, Frank; Marin-Felix, Yasmina;

Departamento: Ciències Mèdiques Bàsiques

e-ISSN: 2309-608X

Autor/es de la URV: MARÍN FÉLIX, YASMINA / Stchigel Glikman, Alberto Miguel

Palabras clave: Sordarins Sordariales Secondary metabolites Naviculisporaceae Cytotoxicity Antimicrobials

Resumen: Triangularia mangenotti was analyzed for the production of secondary metabolites, resulting in the isolation of known zopfinol (1) and its new derivatives zopfinol B-C (2-4), the 10-membered lactones 7-O-acetylmultiplolide A (5) and 8-O-acetylmultiplolide A (6), together with sordarin (7), sordarin B (8), and hypoxysordarin (9). The absolute configuration of 1 was elucidated by the synthesis of MPTA-esters. Compound 1 showed antimicrobial activity against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus and the fungus Mucor hiemalis. While 4 was weakly antibacterial, 3 showed stronger antibiotic activity against the Gram-positive bacteria and weak antifungal activity against M. hiemalis and Rhodotorula glutinis. We furthermore observed the cytotoxicity of 1, 3 and 4 against the mammalian cell lines KB3.1 and L929. Moreover, the new genus Pseudorhypophila is introduced herein to accommodate Triangularia mangenotii together with several species of Zopfiella-Z. marina, Z. pilifera, and Z. submersa. These taxa formed a well-supported monophyletic clade in the recently introduced family Navicularisporaceae, located far from the type species of the respective original genera, in a phylogram based on the combined dataset sequences of the internal transcribed spacer region (ITS), the nuclear rDNA large subunit (LSU), and fragments of the ribosomal polymerase II subunit 2 (rpb2) and beta-tubulin (tub2) genes. Zopfiella submersa is synonymized with P. marina due to the phylogenetic and morphological similarity. The isolation of zopfinols 1-4 and sordarins 7-9 confirms the potential of this fungal order as producers of bioactive compounds and suggests these compounds as potential chemotaxonomic markers.

Áreas temáticas: Plant science Mycology Microbiology (medical) Microbiology Farmacia Ecology, evolution, behavior and systematics Ciências biológicas iii Ciências biológicas ii

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: albertomiguel.stchigel@urv.cat

Identificador del autor: 0000-0003-3987-7996

Fecha de alta del registro: 2023-02-19

Volumen de revista: 7

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/2309-608X/7/3/181

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: J Fungi (Basel). 7 (3): 1-19

Referencia de l'ítem segons les normes APA: Harms, Karen; Milic, Andrea; Stchigel, Alberto M.; Stadler, Marc; Surup, Frank; Marin-Felix, Yasmina; (2021). Three New Derivatives of Zopfinol from Pseudorhypophila Mangenotii gen. et comb. nov.. J Fungi (Basel), 7(3), 1-19. DOI: 10.3390/jof7030181

DOI del artículo: 10.3390/jof7030181

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2021

Tipo de publicación: Journal Publications