Articles producció científica> Medicina i Cirurgia

Lack of Association of Initial Viral Load in SARS-CoV-2 Patients with In-Hospital Mortality

  • Datos identificativos

    Identificador: imarina:9217198
    Autores:
    Carrasquer, AnnaPeiro, Oscar M.Sanchez-Gimenez, RaulLal-Trehan, Nishadel-Moral-Ronda, VictorBonet, GilGutierrez, CristinaFort-Gallifa, IsabelMartin-Grau, CarlaBenavent, ClaraVidal, FrancescBardaji, Alfredo
    Resumen:
    Controversy exists in the literature regarding the possible prognostic implications of the nasopharyngeal SARS-CoV-2 viral load. We carried out a retrospective observational study of 169 patients, 96 (58.9%) of whom had a high viral load and the remaining had a low viral load. Compared with patients with a low viral load, patients with a high viral load did not exhibit differences regarding preexisting cardiovascular risk factors or comorbidities. There were no differences in symptoms, vital signs, or laboratory tests in either group, except for the maximum cardiac troponin I (cTnI), which was higher in the group with a higher viral load (24 [interquartile range 9.5-58.5] versus 8.5 [interquartile range 3-22.5] ng/L, P = 0.007). There were no differences in the need for hospital admission, admission to the intensive care unit, or the need for mechanical ventilation in clinical management. In-hospital mortality was greater in patients who had a higher viral load than in those with low viral load (24% versus 10.4%, P = 0.029). High viral loads were associated with in-hospital mortality in the binary logistic regression analysis (odds ratio: 2.701, 95% Charlson Index (CI): 1.084-6.725, P = 0.033). However, in an analysis adjusted for age, gender, CI, and cTnI, viral load was no longer a predictor of mortality. In conclusion, an elevated nasopharyngeal viral load was not a determinant of in-hospital mortality in patients with COVID-19, as much as age, comorbidity, and myocardial damage determined by elevated cTnI are.
  • Otros:

    Autor según el artículo: Carrasquer, Anna; Peiro, Oscar M.; Sanchez-Gimenez, Raul; Lal-Trehan, Nisha; del-Moral-Ronda, Victor; Bonet, Gil; Gutierrez, Cristina; Fort-Gallifa, Isabel; Martin-Grau, Carla; Benavent, Clara; Vidal, Francesc; Bardaji, Alfredo;
    Departamento: Medicina i Cirurgia
    e-ISSN: 1476-1645
    Autor/es de la URV: Bardají Ruiz, Alfredo / Bonet Pineda, Gil / Carrasquer Cucarella, Ana Maria / Peiró Ibáñez, Óscar Manuel / Sánchez Giménez, Raúl / Vidal Marsal, Francisco
    Palabras clave: Virus load Troponin i Severe acute respiratory syndrome coronavirus 2 Risk factor Retrospective study Real time polymerase chain reaction Prediction Observational study Nonhuman Male Major clinical study Intensive care unit Human Hospital mortality Hospital admission Female Demography Coronavirus disease 2019 Comorbidity Cohort analysis Artificial ventilation Article Aged Adult
    Resumen: Controversy exists in the literature regarding the possible prognostic implications of the nasopharyngeal SARS-CoV-2 viral load. We carried out a retrospective observational study of 169 patients, 96 (58.9%) of whom had a high viral load and the remaining had a low viral load. Compared with patients with a low viral load, patients with a high viral load did not exhibit differences regarding preexisting cardiovascular risk factors or comorbidities. There were no differences in symptoms, vital signs, or laboratory tests in either group, except for the maximum cardiac troponin I (cTnI), which was higher in the group with a higher viral load (24 [interquartile range 9.5-58.5] versus 8.5 [interquartile range 3-22.5] ng/L, P = 0.007). There were no differences in the need for hospital admission, admission to the intensive care unit, or the need for mechanical ventilation in clinical management. In-hospital mortality was greater in patients who had a higher viral load than in those with low viral load (24% versus 10.4%, P = 0.029). High viral loads were associated with in-hospital mortality in the binary logistic regression analysis (odds ratio: 2.701, 95% Charlson Index (CI): 1.084-6.725, P = 0.033). However, in an analysis adjusted for age, gender, CI, and cTnI, viral load was no longer a predictor of mortality. In conclusion, an elevated nasopharyngeal viral load was not a determinant of in-hospital mortality in patients with COVID-19, as much as age, comorbidity, and myocardial damage determined by elevated cTnI are.
    Áreas temáticas: Zootecnia / recursos pesqueiros Virology Tropical medicine Serviço social Saúde coletiva Química Public, environmental & occupational health Psicología Parasitology Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: gil.bonet@urv.cat oscarmanuel.peiro@urv.cat anamaria.carrasquer@urv.cat raul.sanchez@estudiants.urv.cat oscarmanuel.peiro@urv.cat anamaria.carrasquer@urv.cat alfredo.bardaji@urv.cat francesc.vidal@urv.cat
    Identificador del autor: 0000-0003-1900-6974 0000-0002-6692-6186
    Fecha de alta del registro: 2024-07-27
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.ajtmh.org/view/journals/tpmd/104/2/article-p540.xml
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: American Journal Of Tropical Medicine And Hygiene. 104 (2): 540-545
    Referencia de l'ítem segons les normes APA: Carrasquer, Anna; Peiro, Oscar M.; Sanchez-Gimenez, Raul; Lal-Trehan, Nisha; del-Moral-Ronda, Victor; Bonet, Gil; Gutierrez, Cristina; Fort-Gallifa, I (2021). Lack of Association of Initial Viral Load in SARS-CoV-2 Patients with In-Hospital Mortality. American Journal Of Tropical Medicine And Hygiene, 104(2), 540-545. DOI: 10.4269/ajtmh.20-1427
    DOI del artículo: 10.4269/ajtmh.20-1427
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Infectious Diseases,Medicine (Miscellaneous),Parasitology,Public, Environmental & Occupational Health,Tropical Medicine,Virology
    Virus load
    Troponin i
    Severe acute respiratory syndrome coronavirus 2
    Risk factor
    Retrospective study
    Real time polymerase chain reaction
    Prediction
    Observational study
    Nonhuman
    Male
    Major clinical study
    Intensive care unit
    Human
    Hospital mortality
    Hospital admission
    Female
    Demography
    Coronavirus disease 2019
    Comorbidity
    Cohort analysis
    Artificial ventilation
    Article
    Aged
    Adult
    Zootecnia / recursos pesqueiros
    Virology
    Tropical medicine
    Serviço social
    Saúde coletiva
    Química
    Public, environmental & occupational health
    Psicología
    Parasitology
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Matemática / probabilidade e estatística
    Interdisciplinar
    Infectious diseases
    Farmacia
    Ensino
    Engenharias iv
    Enfermagem
    Educação física
    Educação
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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