Autor según el artículo: Sierra-Cruz M; Miguéns-Gómez A; Grau-Bové C; Rodríguez-Gallego E; Blay M; Pinent M; Ardévol A; Terra X; Beltrán-Debón R

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Ardèvol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Pinent Armengol, Montserrat / Terra Barbadora, Ximena

Palabras clave: Proanthocyanidins Obesity Metabolic syndrome Liver steatosis Diet-induced obesity Ageing Adiposity resveratrol proanthocyanidins model metabolic syndrome liver steatosis liver intestinal inflammation insulin-resistance high-fat diet gut microbiota cafeteria diet body-weight ageing adiposity

Resumen: Obesity and ageing are current issues of global concern. Adaptive homeostasis is compromised in the elderly, who are more likely to suffer age-related health issues, such as obesity, metabolic syndrome, and cardiovascular disease. The current worldwide prevalence of obesity and higher life expectancy call for new strategies for treating metabolic disorders. Grape-seed proanthocyanidin extract (GSPE) is reported to be effective in ameliorating these pathologies, especially in young animal models. In this study, we aimed to test the effectiveness of GSPE in modulating obesity-related pathologies in aged rats fed an obesogenic diet. To do so, 21-month-old rats were fed a high-fat/high-sucrose diet (cafeteria diet) for 11 weeks. Two time points for GSPE administration (500 mg/kg body weight), i.e., a 10-day preventive GSPE treatment prior to cafeteria diet intervention and a simultaneous GSPE treatment with the cafeteria diet, were assayed. Body weight, metabolic parameters, liver steatosis, and systemic inflammation were analysed. GSPE administered simultaneously with the cafeteria diet was effective in reducing body weight, total adiposity, and liver steatosis. However, the preventive treatment was effective in reducing only mesenteric adiposity in these obese, aged rats. Our results confirm that the simultaneous administration of GSPE improves metabolic disruptions caused by the cafeteria diet also in aged rats.

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: ximena.terra@urv.cat raul.beltran@urv.cat montserrat.pinent@urv.cat mteresa.blay@urv.cat anna.ardevol@urv.cat

Identificador del autor: 0000-0003-1043-5844 0000-0001-9691-1906 0000-0003-3550-5378 0000-0002-6256-9847 0000-0003-0156-7538

Fecha de alta del registro: 2023-03-05

Volumen de revista: 13

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/2072-6643/13/6/2059

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Nutrients. 13 (6):

Referencia de l'ítem segons les normes APA: Sierra-Cruz M; Miguéns-Gómez A; Grau-Bové C; Rodríguez-Gallego E; Blay M; Pinent M; Ardévol A; Terra X; Beltrán-Debón R (2021). Grape-seed proanthocyanidin extract reverts obesity-related metabolic derangements in aged female rats. Nutrients, 13(6), -. DOI: 10.3390/nu13062059

DOI del artículo: 10.3390/nu13062059

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2021

Tipo de publicación: Journal Publications