Autor según el artículo: Romero-Aroca P; Navarro-Gil R; Feliu A; Valls A; Moreno A; Baget-Bernaldiz M

Departamento: Enginyeria Informàtica i Matemàtiques

Autor/es de la URV: Feliu Rovira, Albert / Moreno Ribas, Antonio / Navarro Gil, Raúl / Romero Aroca, Pedro / Valls Mateu, Aïda

Palabras clave: Systolic blood-pressure Severity of diabetic retinopathy Hba1c variability Hba(1c) variability Hba variability 1c Diabetic retinopathy Coefficient of variation of hba1c Coefficient of variation of hba 1c to-visit variability severity of diabetic retinopathy retinopathy progression prognostic-significance nephropathy microvascular complications microalbuminuria glucose variability follow-up diabetic retinopathy coefficient of variation of hba(1c)

Resumen: Background: To measure the relationship between variability in HbA1c and microalbuminuria (MA) and diabetic retinopathy (DR) in the long term. Methods: A prospective case-series study, was conducted on 366 Type 1 Diabetes Mellitus patients with normoalbuminuria and without diabetic retinopathy at inclusion. The cohort was followed for a period of 12 years. The Cox survival analysis was used for the multivariate statistical study. The effect of variability in microangiopathy (retinopathy and nephropathy) was evaluated by calculating the standard deviation of HbA1c (SD-HbA1c ), the coefficient of variation of HbA1c (CV-HbA1c ), average real variability (ARV-HbA1c ) and variability irrespective of the mean (VIM-HbA1c ) adjusted for the other known variables. Results: A total of 106 patients developed diabetic retinopathy (29%) and 73 microalbuminuria (19.9%). Overt diabetic nephropathy, by our definition, affected only five patients (1.36%). Statistical results show that the current age, mean HbA1c, SD-HbA1c and ARV-HbA1c are significant in the development of diabetic retinopathy. Microalbuminuria was significant for current age, mean HbA1c, CV-HbA1c and ARV-HbA1c . Conclusions: By measuring the variability in HbA1c, we can use SD-HbA1c and ARV-HbA1c as possible targets for judging which patients are at risk of developing DR and MA, and CV-HbA1c as the target for severe DR.

Áreas temáticas: Medicine, general & internal Clinical biochemistry

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: albert.feliu@urv.cat aida.valls@urv.cat pedro.romero@urv.cat antonio.moreno@urv.cat raul.navarrog@estudiants.urv.cat

Identificador del autor: 0000-0003-3616-7809 0000-0002-7061-8987 0000-0003-3945-2314 0000-0003-2970-205X

Fecha de alta del registro: 2023-02-18

Volumen de revista: 11

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/2075-4418/11/7/1151

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Diagnostics. 11 (7):

Referencia de l'ítem segons les normes APA: Romero-Aroca P; Navarro-Gil R; Feliu A; Valls A; Moreno A; Baget-Bernaldiz M (2021). The effect of hba1c variability as a risk measure for microangiopathy in type 1 diabetes mellitus. Diagnostics, 11(7), -. DOI: 10.3390/diagnostics11071151

DOI del artículo: 10.3390/diagnostics11071151

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2021

Tipo de publicación: Journal Publications