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Factors associated with serum ferritin levels and iron excess: results from the EPIC-EurGast study

  • Datos identificativos

    Identificador: imarina:9223786
    Autores:
    Iglesias-Vazquez, LuciaArija, VictoriaAranda, NuriaAglago, Elom K.Cross, Amanda J.Schulze, Matthias B.Quintana Pacheco, DanielKuhn, TilmanWeiderpass, ElisabeteTumino, RosarioRedondo-Sanchez, Danielde Magistris, Maria SantucciPalli, DomenicoArdanaz, EvaLaouali, NasserSonestedt, EmilyDrake, IsabelRizzolo, LuciaSantiuste, CarmenSacerdote, CarlottaQuiros, RamonAmiano, PilarAgudo, AntonioJakszyn, Paula
    Resumen:
    Purpose Excess iron is involved in the development of non-communicable diseases such as cancer, type 2 diabetes and cardiovascular conditions. We aimed to describe the prevalence of excess iron and its determinants in healthy European adults. Methods Sociodemographic, lifestyle, iron status, dietary information, and HFE genotyping were obtained from controls from the nested case-control study EPIC-EurGast study. High sensitivity C-reactive protein (hsCRP) was measured to address possible systemic inflammation. Descriptive and multivariate analyses were used to assess iron status and its determinants. Results Out of the 828 participants (median age: 58.7 years), 43% were females. Median serum ferritin and prevalence of excess iron were 143.7 mu g/L and 35.2% in males, respectively, and 77 mu g/L and 20% in females, both increasing with latitude across Europe. Prevalence of HFE C282Y mutation was significantly higher in Northern and Central Europe (similar to 11%) than in the South (5%). Overweight/obesity, age, and daily alcohol and heme iron intake were independent determinants for iron status, with sex differences even after excluding participants with hsCRP > 5 mg/L. Obese males showed a greater consumption of alcohol, total and red meat, and heme iron, compared with those normal weight. Conclusion Obesity, higher alcohol and heme iron consumption were the main risk factors for excess iron in males while only age was associated with iron overload in females. Weight control and promoting healthy lifestyle may help prevent iron overload, especially in obese people. Further research is needed to clarify determinants of excess iron in the healthy adult population, helping to reduce the associated comorbidities.
  • Otros:

    Autor según el artículo: Iglesias-Vazquez, Lucia; Arija, Victoria; Aranda, Nuria; Aglago, Elom K.; Cross, Amanda J.; Schulze, Matthias B.; Quintana Pacheco, Daniel; Kuhn, Tilman; Weiderpass, Elisabete; Tumino, Rosario; Redondo-Sanchez, Daniel; de Magistris, Maria Santucci; Palli, Domenico; Ardanaz, Eva; Laouali, Nasser; Sonestedt, Emily; Drake, Isabel; Rizzolo, Lucia; Santiuste, Carmen; Sacerdote, Carlotta; Quiros, Ramon; Amiano, Pilar; Agudo, Antonio; Jakszyn, Paula;
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: Aranda Pons, Núria / Arija Val, Maria Victoria / Iglesias Vazquez, Lucia
    Palabras clave: Serum ferritin Risk Physical-activity Overload Iron status Iron overload Hfe c282y Hemochromatosis Excess iron Epic Dietary Danish men Cancer Body iron Alcohol-consumption
    Resumen: Purpose Excess iron is involved in the development of non-communicable diseases such as cancer, type 2 diabetes and cardiovascular conditions. We aimed to describe the prevalence of excess iron and its determinants in healthy European adults. Methods Sociodemographic, lifestyle, iron status, dietary information, and HFE genotyping were obtained from controls from the nested case-control study EPIC-EurGast study. High sensitivity C-reactive protein (hsCRP) was measured to address possible systemic inflammation. Descriptive and multivariate analyses were used to assess iron status and its determinants. Results Out of the 828 participants (median age: 58.7 years), 43% were females. Median serum ferritin and prevalence of excess iron were 143.7 mu g/L and 35.2% in males, respectively, and 77 mu g/L and 20% in females, both increasing with latitude across Europe. Prevalence of HFE C282Y mutation was significantly higher in Northern and Central Europe (similar to 11%) than in the South (5%). Overweight/obesity, age, and daily alcohol and heme iron intake were independent determinants for iron status, with sex differences even after excluding participants with hsCRP > 5 mg/L. Obese males showed a greater consumption of alcohol, total and red meat, and heme iron, compared with those normal weight. Conclusion Obesity, higher alcohol and heme iron consumption were the main risk factors for excess iron in males while only age was associated with iron overload in females. Weight control and promoting healthy lifestyle may help prevent iron overload, especially in obese people. Further research is needed to clarify determinants of excess iron in the healthy adult population, helping to reduce the associated comorbidities.
    Áreas temáticas: Serviço social Saúde coletiva Química Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: nuria.aranda@urv.cat lucia.iglesias@urv.cat victoria.arija@urv.cat
    Identificador del autor: 0000-0001-9708-747X 0000-0001-7131-4144 0000-0002-1758-0975
    Fecha de alta del registro: 2024-08-03
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://link.springer.com/article/10.1007%2Fs00394-021-02625-w
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: European Journal Of Nutrition. 61 (1): 101-114
    Referencia de l'ítem segons les normes APA: Iglesias-Vazquez, Lucia; Arija, Victoria; Aranda, Nuria; Aglago, Elom K.; Cross, Amanda J.; Schulze, Matthias B.; Quintana Pacheco, Daniel; Kuhn, Tilm (2022). Factors associated with serum ferritin levels and iron excess: results from the EPIC-EurGast study. European Journal Of Nutrition, 61(1), 101-114. DOI: 10.1007/s00394-021-02625-w
    DOI del artículo: 10.1007/s00394-021-02625-w
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2022
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Serum ferritin
    Risk
    Physical-activity
    Overload
    Iron status
    Iron overload
    Hfe c282y
    Hemochromatosis
    Excess iron
    Epic
    Dietary
    Danish men
    Cancer
    Body iron
    Alcohol-consumption
    Serviço social
    Saúde coletiva
    Química
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
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