Articles producció científicaMedicina i Cirurgia

Expression of Jejunal Taste Receptors in Women with Morbid Obesity

  • Datos identificativos

    Identificador:  imarina:9225144
    Autores:  Bertran, Laia; Portillo-Carrasquer, Marta; Martinez, Salome; Aguilar, Carmen; Lopez-Dupla, Miguel; Riesco, David; Binetti, Jessica; Vives, Margarita; Sabench, Fatima; Del Castillo, Daniel; Richart, Cristobal; Auguet, Teresa
    Resumen:
    Nutrient sensing plays important roles in promoting satiety and maintaining good homeostatic control. Taste receptors (TAS) are located through the gastrointestinal tract, and recent studies have shown they have a relationship with metabolic disorders. The aim of this study was to analyze the jejunal expression of TAS1R2, TAS1R3, TAS2R14 and TAS2R38 in women with morbid obesity, first classified according to metabolic syndrome presence (MetS; n = 24) or absence (non-MetS; n = 45) and then classified according to hepatic histology as normal liver (n = 28) or nonalcoholic fatty liver disease (n = 41). Regarding MetS, we found decreased expression of TAS2R14 in MetS patients. However, when we subclassified patients according to liver histology, we did not find differences between groups. We found negative correlations between glucose levels, triglycerides and MetS with TAS1R3 expression. Moreover, TAS2R14 jejunal expression correlated negatively with the presence of MetS and ghrelin levels and positively with the jejunal Toll-like receptor (TLR)4, peroxisome proliferator-activated receptor (PPAR)-gamma, and interleukin (IL)-10 levels. Furthermore, TAS2R38 expression correlated negatively with TLR9 jejunal expression and IL-6 levels and positively with TLR4 levels. Our findings suggest that metabolic dysfunctions such as MetS trigger downregulation of the intestinal TASs. Therefore, taste receptors modulation could be a possible therapeutic target for metabolic disorders.
  • Otros:

    Enlace a la fuente original: https://www.mdpi.com/2072-6643/13/7/2437
    Referencia de l'ítem segons les normes APA: Bertran, Laia; Portillo-Carrasquer, Marta; Martinez, Salome; Aguilar, Carmen; Lopez-Dupla, Miguel; Riesco, David; Binetti, Jessica; Vives, Margarita; (2021). Expression of Jejunal Taste Receptors in Women with Morbid Obesity. Nutrients, 13(7), 2437-. DOI: 10.3390/nu13072437
    Referencia al articulo segun fuente origial: Nutrients. 13 (7): 2437-
    DOI del artículo: 10.3390/nu13072437
    Año de publicación de la revista: 2021-07-01
    Entidad: Universitat Rovira i Virgili
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Fecha de alta del registro: 2026-03-02
    Autor/es de la URV: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Bertran Ramos, Laia / Binetti, Jessica Angela / Del Castillo Déjardin, Daniel / López Dupla, Jesús Miguel / Martínez González, María Salomé / Richart Jurado, Cristobal Manuel / Sabench Pereferrer, Fàtima
    Departamento: Medicina i Cirurgia
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Tipo de publicación: Journal Publications
    Autor según el artículo: Bertran, Laia; Portillo-Carrasquer, Marta; Martinez, Salome; Aguilar, Carmen; Lopez-Dupla, Miguel; Riesco, David; Binetti, Jessica; Vives, Margarita; Sabench, Fatima; Del Castillo, Daniel; Richart, Cristobal; Auguet, Teresa
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Volumen de revista: 13
    Áreas temáticas: Zootecnia / recursos pesqueiros, Saúde coletiva, Química, Psicología, Planejamento urbano e regional / demografia, Nutrition and dietetics, Nutrition & dietetics, Nutrição, Medicina veterinaria, Medicina iii, Medicina ii, Medicina i, Interdisciplinar, Food science, Farmacia, Engenharias iv, Engenharias ii, Enfermagem, Educação física, Economia, Ciências biológicas iii, Ciências biológicas ii, Ciências biológicas i, Ciências agrárias i, Ciência de alimentos, Biotecnología
    Direcció de correo del autor: jessicaangela.binetti@urv.cat, mariasalome.martinez@urv.cat, danieldel.castillo@urv.cat, cristobalmanuel.richart@urv.cat, jessicaangela.binetti@urv.cat, jessicaangela.binetti@urv.cat, laia.bertranr@estudiants.urv.cat, laia.bertranr@estudiants.urv.cat, fatima.sabench@urv.cat, carmenisabel.aguilar@urv.cat, carmenisabel.aguilar@urv.cat, mariateresa.auguet@urv.cat, jesusmiguel.lopez@urv.cat
  • Palabras clave:

    Unclassified drug
    Triacylglycerol
    Toll like receptor 9
    Toll like receptor 4
    Toll like receptor 2
    Taste receptors
    type 2
    type 1
    Taste bud
    Taste 2 receptor 38
    Taste 2 receptor 14
    Taste 1 receptor 3
    Taste 1 receptor 2
    Taste
    Sweetness
    Steatohepatitis
    Release
    Receptors
    g-protein-coupled
    Receptor
    Real time polymerase chain reaction
    Protein expression
    Peroxisome proliferator activated receptor gamma
    Peroxisome proliferator activated receptor alpha
    Pathology
    Obesity
    morbid
    Nonalcoholic fatty liver disease
    Nonalcoholic fatty liver
    Non-alcoholic fatty liver disease
    Morbid obesity
    Metabolism
    Metabolic syndrome x
    Metabolic syndrome
    Management
    Low density lipoprotein cholesterol
    Liver histology
    Liver
    Lipid metabolism
    Jejunum
    Interleukin 8
    Interleukin 6
    Interleukin 1beta
    Interleukin 17
    Interleukin 10
    Insulin
    Inflammation
    Impact
    Humans
    Human tissue
    Human
    High density lipoprotein cholesterol
    Health
    Gut microbiota
    Good health and well-being
    Glyceraldehyde 3 phosphate dehydrogenase
    Glucose level
    Glucose
    Ghrelin
    Genetics
    Gene expression
    Gastrointestinal tract
    Gamma glutamyltransferase
    G protein coupled receptor
    Female
    Fatty liver-disease
    Down-regulation
    Down regulation
    Controlled study
    Complication
    Clinical feature
    Clinical assessment
    Clinical article
    Cholesterol
    Bitter taste
    Association
    Aspartate aminotransferase
    Article
    Alkaline phosphatase
    Alanine aminotransferase
    Adult
    Adipocytokine
    Food Science
    Nutrition & Dietetics
    Nutrition and Dietetics
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação físi
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