Autor según el artículo: Bertran, Laia; Portillo-Carrasquer, Marta; Martinez, Salome; Aguilar, Carmen; Lopez-Dupla, Miguel; Riesco, David; Binetti, Jessica; Vives, Margarita; Sabench, Fatima; Del Castillo, Daniel; Richart, Cristobal; Auguet, Teresa
Departamento: Medicina i Cirurgia
Autor/es de la URV: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Bertran Ramos, Laia / Binetti, Jessica Angela / Del Castillo Déjardin, Daniel / López Dupla, Jesús Miguel / Richart Jurado, Cristobal Manuel / Sabench Pereferrer, Fàtima
Palabras clave: Unclassified drug Triacylglycerol Toll like receptor 9 Toll like receptor 4 Toll like receptor 2 Taste receptors, type 2 Taste receptors, type 1 Taste receptors Taste bud Taste 2 receptor 38 Taste 2 receptor 14 Taste 1 receptor 3 Taste 1 receptor 2 Taste Sweetness Steatohepatitis Release Receptors, g-protein-coupled Receptor Real time polymerase chain reaction Protein expression Peroxisome proliferator activated receptor gamma Peroxisome proliferator activated receptor alpha Pathology Obesity, morbid Nonalcoholic fatty liver disease Nonalcoholic fatty liver Non-alcoholic fatty liver disease Morbid obesity Metabolism Metabolic syndrome x Metabolic syndrome Management Low density lipoprotein cholesterol Liver histology Liver Lipid metabolism Jejunum Interleukin 8 Interleukin 6 Interleukin 1beta Interleukin 17 Interleukin 10 Insulin Inflammation Impact Humans Human tissue Human High density lipoprotein cholesterol Health Gut microbiota Glyceraldehyde 3 phosphate dehydrogenase Glucose level Glucose Ghrelin Genetics Gene expression Gastrointestinal tract Gamma glutamyltransferase G protein coupled receptor Female Fatty liver-disease Down-regulation Down regulation Controlled study Complication Clinical feature Clinical assessment Clinical article Cholesterol Bitter taste Association Aspartate aminotransferase Article Alkaline phosphatase Alanine aminotransferase Adult Adipocytokine
Resumen: Nutrient sensing plays important roles in promoting satiety and maintaining good homeostatic control. Taste receptors (TAS) are located through the gastrointestinal tract, and recent studies have shown they have a relationship with metabolic disorders. The aim of this study was to analyze the jejunal expression of TAS1R2, TAS1R3, TAS2R14 and TAS2R38 in women with morbid obesity, first classified according to metabolic syndrome presence (MetS; n = 24) or absence (non-MetS; n = 45) and then classified according to hepatic histology as normal liver (n = 28) or nonalcoholic fatty liver disease (n = 41). Regarding MetS, we found decreased expression of TAS2R14 in MetS patients. However, when we subclassified patients according to liver histology, we did not find differences between groups. We found negative correlations between glucose levels, triglycerides and MetS with TAS1R3 expression. Moreover, TAS2R14 jejunal expression correlated negatively with the presence of MetS and ghrelin levels and positively with the jejunal Toll-like receptor (TLR)4, peroxisome proliferator-activated receptor (PPAR)-gamma, and interleukin (IL)-10 levels. Furthermore, TAS2R38 expression correlated negatively with TLR9 jejunal expression and IL-6 levels and positively with TLR4 levels. Our findings suggest that metabolic dysfunctions such as MetS trigger downregulation of the intestinal TASs. Therefore, taste receptors modulation could be a possible therapeutic target for metabolic disorders.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: danieldel.castillo@urv.cat jessicaangela.binetti@estudiants.urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat fatima.sabench@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat jesusmiguel.lopez@urv.cat
Identificador del autor: 0000-0003-0456-3102 0000-0001-7024-7824 0000-0001-9660-7752 0000-0001-9052-1368 0000-0001-9052-1368 0000-0002-9262-8756 0000-0002-4440-562X 0000-0002-4440-562X https://orcid.org/0000-0003-0396-6428 0000-0003-0396-6428 0000-0002-9141-2523
Fecha de alta del registro: 2024-12-21
Volumen de revista: 13
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Nutrients. 13 (7): 2437-
Referencia de l'ítem segons les normes APA: Bertran, Laia; Portillo-Carrasquer, Marta; Martinez, Salome; Aguilar, Carmen; Lopez-Dupla, Miguel; Riesco, David; Binetti, Jessica; Vives, Margarita; (2021). Expression of Jejunal Taste Receptors in Women with Morbid Obesity. Nutrients, 13(7), 2437-. DOI: 10.3390/nu13072437
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV