Autor según el artículo: Papandreou, Christopher; Garcia-Gavilan, Jesus; Camacho-Barcia, Lucia; Toft Hansen, Thea; Harrold, Joanne A.; Sjodin, Anders; Halford, Jason C. G.; Bullo, Monica;

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Bulló Bonet, Mònica

Palabras clave: Weight maintenance Weight loss Satin Phospholipids Overweight Obese adults Metabolomics Metaanalysis Management Loss diets Intervention Insulin-resistance Individuals Bone

Resumen: Scope To examine the relationship between changes in circulating metabolites during diet-induced weight loss and changes of adiposity. This study also investigates changes in these metabolites in relation to body weight and adiposity regain during a weight loss maintenance period. Methods and Results This cohort study is nested within the Satiety Innovation (SATIN) study. Participants (n = 162) achieving >= 8% weight loss during an initial 8-week low-calorie formula diet (LCD) are included in a 12-week weight loss maintenance period. A targeted metabolite profiling (123 metabolites) approach is applied using three different platforms (proton nuclear magnetic resonance, liquid chromatography mass spectrometry, gas chromatography mass spectrometry). Changes in several lipid species and citric acid are significantly associated with greater reduction of body weight, total fat, and abdominal adiposity distribution during the LCD. Decreases in the concentrations of lysophosphatidylcholines (LPCs) 14:0, LPC 20:3, phosphatidylcholine (PC) 32:2, PC 38:3, sphingomyelin (SM) 32:2, and increases in citric acid concentrations during the LCD are associated with adiposity regain and loss, respectively, during the weight loss maintenance period. Conclusions The results show that weight loss is associated with changes in lipid species and citric acid. These changes are related to subsequent weight and adiposity regain identifying the adipose lipid metabolism as an important factor for the maintenance of lost weight and adiposity.

Áreas temáticas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: monica.bullo@urv.cat

Identificador del autor: 0000-0002-0218-7046

Fecha de alta del registro: 2023-02-19

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202001154

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Molecular Nutrition & Food Research. 65 (17):

Referencia de l'ítem segons les normes APA: Papandreou, Christopher; Garcia-Gavilan, Jesus; Camacho-Barcia, Lucia; Toft Hansen, Thea; Harrold, Joanne A.; Sjodin, Anders; Halford, Jason C. G.; Bu (2021). Changes in Circulating Metabolites During Weight Loss are Associated with Adiposity Improvement, and Body Weight and Adiposity Regain During Weight Loss Maintenance: The SATIN Study. Molecular Nutrition & Food Research, 65(17), -. DOI: 10.1002/mnfr.202001154

DOI del artículo: 10.1002/mnfr.202001154

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2021

Tipo de publicación: Journal Publications