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Silicon-Based Laser Desorption Ionization Mass Spectrometry for the Analysis of Biomolecules: A Progress Report

  • Datos identificativos

    Identificador: imarina:9226662
    Handle: https://hdl.handle.net/20.500.11797/imarina9226662
    Autores:
    Alexandra Iakab, StefaniaRafols, PereGarcia-Altares, MariaYanes, OscarCorreig, Xavier
    Resumen:
    Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is widely used in the biomedical field for the label-free analysis of molecules such as drugs, lipids, peptides, proteins, and biological tissues for molecular imaging. However, organic matrices used in traditional MALDI-MS applications introduce excessive interferences in the low m/z range. For this reason, nanostructured materials-and in particular silicon-based LDI strategies-have become a promising alternative, since they provide a much weaker background. Herein, the recent developments in fabrication, functionalization, and practical applications of silicon-based LDI-MS methods are reviewed. Also the basic requirements of silicon-based substrates for optimal LDI analysis by providing an overview of the LDI mechanisms that use silicon-based substrates instead of organic matrices are reported. Finally, the considerable potential of silicon-based substrates is discussed, giving suggestions for topics for future research.

  • Otros:

    Autor según el artículo: Alexandra Iakab, Stefania; Rafols, Pere; Garcia-Altares, Maria; Yanes, Oscar; Correig, Xavier
    Departamento: Enginyeria Electrònica, Elèctrica i Automàtica
    Autor/es de la URV: Correig Blanchar, Francesc Xavier / Garcia-Altares Pérez, Maria / Ràfols Soler, Pere / Yanes Torrado, Óscar
    Palabras clave: Surface functionalization Silver nanoparticles Silicon nanostructures Selective enrichment Nanowire arrays Nanostructure Ms analysis Modified porous silicon Mass spectrometry imaging (msi) Maldi Laser desorption ionization (ldi) Ion formation High-sensitivity Desorption/ionization
    Resumen: Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is widely used in the biomedical field for the label-free analysis of molecules such as drugs, lipids, peptides, proteins, and biological tissues for molecular imaging. However, organic matrices used in traditional MALDI-MS applications introduce excessive interferences in the low m/z range. For this reason, nanostructured materials-and in particular silicon-based LDI strategies-have become a promising alternative, since they provide a much weaker background. Herein, the recent developments in fabrication, functionalization, and practical applications of silicon-based LDI-MS methods are reviewed. Also the basic requirements of silicon-based substrates for optimal LDI analysis by providing an overview of the LDI mechanisms that use silicon-based substrates instead of organic matrices are reported. Finally, the considerable potential of silicon-based substrates is discussed, giving suggestions for topics for future research.
    Áreas temáticas: Química Physics, condensed matter Physics, applied Nanoscience and nanotechnology Nanoscience & nanotechnology Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) Materiais General materials science General chemistry Engenharias iv Engenharias ii Electronic, optical and magnetic materials Electrochemistry Condensed matter physics Ciências agrárias i Chemistry, physical Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Biomaterials Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: oscar.yanes@urv.cat maria.garcia-altares@urv.cat pere.rafols@urv.cat xavier.correig@urv.cat
    Identificador del autor: 0000-0003-3695-7157 0000-0002-9240-4058 0000-0002-6902-3054
    Fecha de alta del registro: 2024-10-12
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Advanced Functional Materials. 29 (45): 1903609-
    Referencia de l'ítem segons les normes APA: Alexandra Iakab, Stefania; Rafols, Pere; Garcia-Altares, Maria; Yanes, Oscar; Correig, Xavier (2019). Silicon-Based Laser Desorption Ionization Mass Spectrometry for the Analysis of Biomolecules: A Progress Report. Advanced Functional Materials, 29(45), 1903609-. DOI: 10.1002/adfm.201903609
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2019
    Tipo de publicación: Journal Publications

  • Palabras clave:

    Biomaterials,Chemistry (Miscellaneous),Chemistry, Multidisciplinary,Chemistry, Physical,Condensed Matter Physics,Electrochemistry,Electronic, Optical and Magnetic Materials,Materials Science (Miscellaneous),Materials Science, Multidisciplinary,Nanoscience & Nanotechnology,Nanoscience and Nanotechnology,Physics, Applied,Physics, Condensed M
    Surface functionalization
    Silver nanoparticles
    Silicon nanostructures
    Selective enrichment
    Nanowire arrays
    Nanostructure
    Ms analysis
    Modified porous silicon
    Mass spectrometry imaging (msi)
    Maldi
    Laser desorption ionization (ldi)
    Ion formation
    High-sensitivity
    Desorption/ionization
    Química
    Physics, condensed matter
    Physics, applied
    Nanoscience and nanotechnology
    Nanoscience & nanotechnology
    Materials science, multidisciplinary
    Materials science (miscellaneous)
    Materials science (all)
    Materiais
    General materials science
    General chemistry
    Engenharias iv
    Engenharias ii
    Electronic, optical and magnetic materials
    Electrochemistry
    Condensed matter physics
    Ciências agrárias i
    Chemistry, physical
    Chemistry, multidisciplinary
    Chemistry (miscellaneous)
    Chemistry (all)
    Biomaterials
    Astronomia / física

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