Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice

  • Datos identificativos

    Identificador: imarina:9227050
    Autores:
    Vinaixa, MariaCanelles, SandraGonzalez-Murillo, AfricaFerreira, VitorGrajales, DianaGuerra-Cantera, SantiagoCampillo-Calatayud, AnaRamirez-Orellana, ManuelYanes, OscarFrago, Laura MValverde, Angela MBarrios, Vicente
    Resumen:
    Insulin receptor substrate (IRS) 2 is a key mediator of insulin signaling and IRS-2 knockout (IRS2(-/-)) mice are a preclinical model to study the development of diabetes, as they develop peripheral insulin resistance and beta-cell failure. The differential inflammatory profile and insulin signaling in the hypothalamus of non-diabetic (ND) and diabetic (D) IRS2(-/-) mice might be implicated in the onset of diabetes. Because the lipid profile is related to changes in inflammation and insulin sensitivity, we analyzed whether ND IRS2(-/-) mice presented a different hypothalamic fatty acid metabolism and lipid pattern than D IRS2(-/-) mice and the relationship with inflammation and markers of insulin sensitivity. ND IRS2(-/-) mice showed elevated hypothalamic anti-inflammatory cytokines, while D IRS2(-/-) mice displayed a proinflammatory profile. The increased activity of enzymes related to the pentose-phosphate route and lipid anabolism and elevated polyunsaturated fatty acid levels were found in the hypothalamus of ND IRS2(-/-) mice. Conversely, D IRS2(-/-) mice have no changes in fatty acid composition, but hypothalamic energy balance and markers related to anti-inflammatory and insulin-sensitizing properties were reduced. The data suggest that the concurrence of an anti-inflammatory profile, increased insulin sensitivity and polyunsaturated fatty acids content in the hypothalamus may slow down or delay the onset of diabetes.
  • Otros:

    Autor según el artículo: Vinaixa, Maria; Canelles, Sandra; Gonzalez-Murillo, Africa; Ferreira, Vitor; Grajales, Diana; Guerra-Cantera, Santiago; Campillo-Calatayud, Ana; Ramirez-Orellana, Manuel; Yanes, Oscar; Frago, Laura M; Valverde, Angela M; Barrios, Vicente
    Departamento: Enginyeria Electrònica, Elèctrica i Automàtica
    Autor/es de la URV: Vinaixa Crevillent, Maria / Yanes Torrado, Óscar
    Palabras clave: Sensitivity Pufa Pathway Pathogenesis Oxidative stress Obesity Modulation Mice, knockout Mice, inbred c57bl Mice Metabolism Lipid metabolism Leptin Irs2−/− mice Irs2 protein, mouse Irs2 Interleukin-1beta Insulin receptor substrate proteins Inhibition Inflammation Hypothalamus Glucose transport proteins, facilitative Fatty acids, unsaturated Expression Energy metabolism Diabetes mellitus, experimental Diabetes Cytokines Chemokine cx3cl1 Blood glucose Animals
    Resumen: Insulin receptor substrate (IRS) 2 is a key mediator of insulin signaling and IRS-2 knockout (IRS2(-/-)) mice are a preclinical model to study the development of diabetes, as they develop peripheral insulin resistance and beta-cell failure. The differential inflammatory profile and insulin signaling in the hypothalamus of non-diabetic (ND) and diabetic (D) IRS2(-/-) mice might be implicated in the onset of diabetes. Because the lipid profile is related to changes in inflammation and insulin sensitivity, we analyzed whether ND IRS2(-/-) mice presented a different hypothalamic fatty acid metabolism and lipid pattern than D IRS2(-/-) mice and the relationship with inflammation and markers of insulin sensitivity. ND IRS2(-/-) mice showed elevated hypothalamic anti-inflammatory cytokines, while D IRS2(-/-) mice displayed a proinflammatory profile. The increased activity of enzymes related to the pentose-phosphate route and lipid anabolism and elevated polyunsaturated fatty acid levels were found in the hypothalamus of ND IRS2(-/-) mice. Conversely, D IRS2(-/-) mice have no changes in fatty acid composition, but hypothalamic energy balance and markers related to anti-inflammatory and insulin-sensitizing properties were reduced. The data suggest that the concurrence of an anti-inflammatory profile, increased insulin sensitivity and polyunsaturated fatty acids content in the hypothalamus may slow down or delay the onset of diabetes.
    Áreas temáticas: Medicine (miscellaneous) Cell biology Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all)
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: maria.vinaixa@urv.cat oscar.yanes@urv.cat maria.vinaixa@urv.cat
    Identificador del autor: 0000-0001-9804-0171 0000-0003-3695-7157 0000-0001-9804-0171
    Fecha de alta del registro: 2024-10-12
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2073-4409/10/8/2085
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Cells. 10 (8): 2085-
    Referencia de l'ítem segons les normes APA: Vinaixa, Maria; Canelles, Sandra; Gonzalez-Murillo, Africa; Ferreira, Vitor; Grajales, Diana; Guerra-Cantera, Santiago; Campillo-Calatayud, Ana; Ramir (2021). Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice. Cells, 10(8), 2085-. DOI: 10.3390/cells10082085
    DOI del artículo: 10.3390/cells10082085
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry, Genetics and Molecular Biology (Miscellaneous),Cell Biology,Medicine (Miscellaneous)
    Sensitivity
    Pufa
    Pathway
    Pathogenesis
    Oxidative stress
    Obesity
    Modulation
    Mice, knockout
    Mice, inbred c57bl
    Mice
    Metabolism
    Lipid metabolism
    Leptin
    Irs2−/− mice
    Irs2 protein, mouse
    Irs2
    Interleukin-1beta
    Insulin receptor substrate proteins
    Inhibition
    Inflammation
    Hypothalamus
    Glucose transport proteins, facilitative
    Fatty acids, unsaturated
    Expression
    Energy metabolism
    Diabetes mellitus, experimental
    Diabetes
    Cytokines
    Chemokine cx3cl1
    Blood glucose
    Animals
    Medicine (miscellaneous)
    Cell biology
    Biochemistry, genetics and molecular biology (miscellaneous)
    Biochemistry, genetics and molecular biology (all)
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