Autor según el artículo: Vinaixa, Maria; Canelles, Sandra; Gonzalez-Murillo, Africa; Ferreira, Vitor; Grajales, Diana; Guerra-Cantera, Santiago; Campillo-Calatayud, Ana; Ramirez-Orellana, Manuel; Yanes, Oscar; Frago, Laura M.; Valverde, Angela M.; Barrios, Vicente;

Departamento: Enginyeria Electrònica, Elèctrica i Automàtica

Autor/es de la URV: Vinaixa Crevillent, Maria / Yanes Torrado, Óscar

Palabras clave: Sensitivity Pufa Pathway Pathogenesis Oxidative stress Obesity Modulation Mice Metabolism Irs2−/− mice Irs2 Inhibition Inflammation Hypothalamus Expression Diabetes

Resumen: Insulin receptor substrate (IRS) 2 is a key mediator of insulin signaling and IRS-2 knockout (IRS2(-/-)) mice are a preclinical model to study the development of diabetes, as they develop peripheral insulin resistance and beta-cell failure. The differential inflammatory profile and insulin signaling in the hypothalamus of non-diabetic (ND) and diabetic (D) IRS2(-/-) mice might be implicated in the onset of diabetes. Because the lipid profile is related to changes in inflammation and insulin sensitivity, we analyzed whether ND IRS2(-/-) mice presented a different hypothalamic fatty acid metabolism and lipid pattern than D IRS2(-/-) mice and the relationship with inflammation and markers of insulin sensitivity. ND IRS2(-/-) mice showed elevated hypothalamic anti-inflammatory cytokines, while D IRS2(-/-) mice displayed a proinflammatory profile. The increased activity of enzymes related to the pentose-phosphate route and lipid anabolism and elevated polyunsaturated fatty acid levels were found in the hypothalamus of ND IRS2(-/-) mice. Conversely, D IRS2(-/-) mice have no changes in fatty acid composition, but hypothalamic energy balance and markers related to anti-inflammatory and insulin-sensitizing properties were reduced. The data suggest that the concurrence of an anti-inflammatory profile, increased insulin sensitivity and polyunsaturated fatty acids content in the hypothalamus may slow down or delay the onset of diabetes.

Áreas temáticas: Medicine (miscellaneous) Cell biology Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all)

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: maria.vinaixa@urv.cat oscar.yanes@urv.cat maria.vinaixa@urv.cat

Identificador del autor: 0000-0001-9804-0171 0000-0003-3695-7157 0000-0001-9804-0171

Fecha de alta del registro: 2023-02-19

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/2073-4409/10/8/2085

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Cells. 10 (8):

Referencia de l'ítem segons les normes APA: Vinaixa, Maria; Canelles, Sandra; Gonzalez-Murillo, Africa; Ferreira, Vitor; Grajales, Diana; Guerra-Cantera, Santiago; Campillo-Calatayud, Ana; Ramir (2021). Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice. Cells, 10(8), -. DOI: 10.3390/cells10082085

DOI del artículo: 10.3390/cells10082085

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2021

Tipo de publicación: Journal Publications