Autor según el artículo: Muralidharan, Jananee; Moreno-Indias, Isabel; Bullo, Monica; Vioque Lopez, Jesus; Corella, Dolores; Castaner, Olga; Vidal, Josep; Atzeni, Alessandro; Carlos Fernandez-Garcia, Jose; Torres-Collado, Laura; Fernandez-Carrion, Rebeca; Fito, Monsterrat; Olbeyra, Romina; Maria Gomez-Perez, Ana; Galie, Serena; Rosa Bernal-Lopez, Maria; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Jose Tinahones, Francisco
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Atzeni, Alessandro / Bulló Bonet, Mònica / Galiè, Serena / Martínez Rodríguez, María Ángeles / Muralidharan, Jananee / Salas Salvadó, Jorge
Palabras clave: Weight loss Rna, ribosomal, 16s Rna, bacterial Rna 16s Randomized controlled trial Phylogeny Overweight Obesity Middle aged Microbiology Metabolic syndrome x Metabolic syndrome Men Mediterranean diet Male Lifestyle Life style Intestine flora Humans Human Gut microbiota Genetics Gastrointestinal microbiome Female Feces Exercise Energy restriction Energy intake Diet, mediterranean Controlled study Classification Caloric restriction Caloric intake Bacterium Bacterial rna Bacteria Aged
Resumen: Background: The Mediterranean diet is a well-recognized healthy diet that has shown to induce positive changes in gut microbiota. Lifestyle changes such as diet along with physical activity could aid in weight loss and improve cardiovascular risk factors.Objectives: To investigate the effect of an intensive lifestyle weight loss intervention on gut microbiota.Methods: This is a substudy of the PREDIMED-Plus (Prevention con Dieta Mediterrdnea-Plus), a randomized controlled trial conducted in overweight/obese men and women (aged 55-75 y) with metabolic syndrome. The intervention group (IG) underwent an intensive weight loss lifestyle intervention based on an energy-restricted Mediterranean diet (MedDiet) and physical activity promotion. and the control group ((Xi) underwent a non-energy-restricted MedDiet for 1 y. Anthropometric, biochemical, and gut microbial 16S rRNA sequencing data were analyzed at baseline (n = 362) and 1-y follow-up (n = 343).Results: IG participants had a weight loss of 4.2 (IQR, -6.8, -2.5) kg compared with 0.2 (IQR, -2.1. 1.4) kg in the CG (P < 0.001). Reductions in BMI, fasting glucose, glycated hemoglobin, and triglycerides and an increase in HDL cholesterol were greater in IG than inCG participants (P < 0.05). We observed a decrease in Butyricicoccus, Haentophilus. Ruminiclostridium 5, and Eubacterium hall in the IG compared with the CG. Many genera shifted in the same direction within both intervention groups, indicating an overall effect of the MedDiet. Decreases in Themophilus. Coprococcus 3, and few other genera were associated with a decrease in adiposity parameters in both intervention groups. Changes in Lachnospiraceae NK4A136 were positively associated with changes in MedDiet adherence.Conclusions: Weight loss induced by an energy-restricted MedDiet and physical activity induce changes in gut microbiota. The role of MedDiet-induced changes on the host might be via short-chain fatty acid producing bacteria, whereas with energy restriction, these changes might be modulated with other mechanisms, which need to be explored in future studies.
Áreas temáticas: Serviço social Saúde coletiva Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i General medicine Enfermagem Educação física Ciências biológicas ii Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: alessandro.atzeni@urv.cat mangeles.martinez@urv.cat alessandro.atzeni@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat
Identificador del autor: 0000-0002-1804-8606 0000-0001-8595-3772 0000-0002-1804-8606 0000-0002-0218-7046 0000-0003-2700-7459
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: American Journal Of Clinical Nutrition. 114 (3): 1148-1158
Referencia de l'ítem segons les normes APA: Muralidharan, Jananee; Moreno-Indias, Isabel; Bullo, Monica; Vioque Lopez, Jesus; Corella, Dolores; Castaner, Olga; Vidal, Josep; Atzeni, Alessandro; (2021). Effect on gut microbiota of a 1-y lifestyle intervention with Mediterranean diet compared with energy-reduced Mediterranean diet and physical activity promotion: PREDIMED-Plus Study. American Journal Of Clinical Nutrition, 114(3), 1148-1158. DOI: 10.1093/ajcn/nqab150
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV