Articles producció científica> Ciències Mèdiques Bàsiques

Slow-wave sleep and androgens: selective slow-wave sleep suppression affects testosterone and 17α-hydroxyprogesterone secretion

  • Datos identificativos

    Identificador: imarina:9230579
    Autores:
    Ukraintseva YLiaukovich KPolishchuk AMartynova VBelov DSimenel EMeira e CruzNizhnik N
    Resumen:
    Objectives: Levels of steroid hormones such as androgens and cortisol exhibit circadian variation, and their fluctuations are related to the sleep-wake cycle. Currently, the functional role of different stages of sleep in steroid hormone secretion remains unclear. The present study aims to explore the effect of slow-wave sleep (SWS) suppression on morning levels of cortisol and androgens. Methods: Twelve healthy male volunteers participated in two experimental sessions: a session with selective SWS suppression during night sleep and a session with regular night sleep (control). SWS suppression was achieved by stimulation using an acoustic tone. Salivary samples were collected in the morning immediately after awakening and again 40 min later. The samples were analysed by liquid chromatography-tandem mass spectrometry for testosterone, androstenedione (Ad), dehydroepiandrosterone (DHEA), 17α-hydroxyprogesterone (17-OHP), and cortisol. Results: SWS suppression reduced overall SWS duration by 54.2% without significant changes in total sleep time and sleep efficiency. In the session with selective SWS suppression, the average level of morning testosterone was lower than in the control session (p = 0.017). Likewise, 17-OHP was lower in the SWS suppression condition (p = 0.011) whereas the ratio of DHEA/Ad was higher (p = 0.025). There were no significant differences between sessions in cortisol, Ad, or DHEA concentrations. Conclusions: The effect of selective SWS suppression on morning levels of testosterone and 17-OHP points to the importance of SWS for the synthesis and secretion of androgens. These results suggest that chronic sleep problems, which lead to reduced SWS, increase the risk for the development of androgen deficiency in the long term.
  • Otros:

    Autor según el artículo: Ukraintseva Y; Liaukovich K; Polishchuk A; Martynova V; Belov D; Simenel E; Meira e Cruz; Nizhnik N
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: Polishchuk, Aleksandra
    Palabras clave: Testosterone Slow-wave sleep Dehydroepiandrosterone Cortisol Androstenedione 17α-hydroxyprogesterone
    Resumen: Objectives: Levels of steroid hormones such as androgens and cortisol exhibit circadian variation, and their fluctuations are related to the sleep-wake cycle. Currently, the functional role of different stages of sleep in steroid hormone secretion remains unclear. The present study aims to explore the effect of slow-wave sleep (SWS) suppression on morning levels of cortisol and androgens. Methods: Twelve healthy male volunteers participated in two experimental sessions: a session with selective SWS suppression during night sleep and a session with regular night sleep (control). SWS suppression was achieved by stimulation using an acoustic tone. Salivary samples were collected in the morning immediately after awakening and again 40 min later. The samples were analysed by liquid chromatography-tandem mass spectrometry for testosterone, androstenedione (Ad), dehydroepiandrosterone (DHEA), 17α-hydroxyprogesterone (17-OHP), and cortisol. Results: SWS suppression reduced overall SWS duration by 54.2% without significant changes in total sleep time and sleep efficiency. In the session with selective SWS suppression, the average level of morning testosterone was lower than in the control session (p = 0.017). Likewise, 17-OHP was lower in the SWS suppression condition (p = 0.011) whereas the ratio of DHEA/Ad was higher (p = 0.025). There were no significant differences between sessions in cortisol, Ad, or DHEA concentrations. Conclusions: The effect of selective SWS suppression on morning levels of testosterone and 17-OHP points to the importance of SWS for the synthesis and secretion of androgens. These results suggest that chronic sleep problems, which lead to reduced SWS, increase the risk for the development of androgen deficiency in the long term.
    Áreas temáticas: Saúde coletiva Odontología Nutrição Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ensino Engenharias iv Educação física Educação Clinical neurology Ciências biológicas ii Antropologia / arqueologia
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: aleksandra.polishchuk@urv.cat aleksandra.polishchuk@urv.cat
    Identificador del autor: 0000-0001-6445-1538 0000-0001-6445-1538
    Fecha de alta del registro: 2022-07-24
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S1389945718301771?via%3Dihub#!
    Referencia al articulo segun fuente origial: Sleep Medicine. 48 117-126
    Referencia de l'ítem segons les normes APA: Ukraintseva Y; Liaukovich K; Polishchuk A; Martynova V; Belov D; Simenel E; Meira e Cruz; Nizhnik N (2018). Slow-wave sleep and androgens: selective slow-wave sleep suppression affects testosterone and 17α-hydroxyprogesterone secretion. Sleep Medicine, 48(), 117-126. DOI: 10.1016/j.sleep.2018.04.012
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1016/j.sleep.2018.04.012
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2018
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Clinical Neurology,Medicine (Miscellaneous)
    Testosterone
    Slow-wave sleep
    Dehydroepiandrosterone
    Cortisol
    Androstenedione
    17α-hydroxyprogesterone
    Saúde coletiva
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicine (all)
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Ensino
    Engenharias iv
    Educação física
    Educação
    Clinical neurology
    Ciências biológicas ii
    Antropologia / arqueologia
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