Autor según el artículo: Gomez-Martinez, Carlos; Babio, Nancy; Julvez, Jordi; Becerra-Tomas, Nerea; Martinez-Gonzalez, Miguel A; Corella, Dolores; Castaner, Olga; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M; Warnberg, Julia; Martinez, Jose A; Serra-Majem, Luis; Estruch, Ramon; Tinahones, Francisco J; Lapetra, Jose; Pinto, Xavier; Tur, Josep A; Lopez-Miranda, Jose; Bueno-Cavanillas, Aurora; Gaforio, Jose J; Matia-Martin, Pilar; Daimiel, Lidia; Martin-Sanchez, Vicente; Vidal, Josep; Vazquez, Clotilde; Ros, Emilio; Dalsgaard, Soren; Sayon-Orea, Carmen; Sorli, Jose, V; de la Torre, Rafael; Abete, Itziar; Tojal-Sierra, Lucas; Baron-Lopez, Francisco J; Fernandez-Brufal, Noelia; Konieczna, Jadwiga; Garcia-Rios, Antonio; Sacanella, Emilio; Bernal-Lopez, M Rosa; Santos-Lozano, Jose M; Razquin, Cristina; Alvarez-Sala, Andrea; Goday, Albert; Angeles Zulet, M; Vaquero-Luna, Jessica; Diez-Espino, Javier; Cuenca-Royo, Aida; Fernandez-Aranda, Fernando; Bullo, Monica; Salas-Salvado, Jordi
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Babio Sánchez, Nancy Elvira / Becerra Tomás, Nerea / Bulló Bonet, Mònica / Salas Salvadó, Jorge
Palabras clave: Working memory; Validation; Type 2 diabetes; Trail making test; Sex difference; Sensitivity analysis; Randomized controlled trial; Prospective study; Processing speed; Prevalence; Prediabetes; Physical-activity questionnaire; Physical activity; Parallel design; Observational study; Obesity; Non insulin dependent diabetes mellitus; Multicenter study; Mini mental state examination; Middle aged; Metabolic syndrome x; Metaanalysis; Male; Major clinical study; Insulin-resistance; Insulin treatment; Insulin resistance; Insulin; Impaired glucose tolerance; Hypoglycemic episodes; Hypertension; Hypercholesterolemia; Human; Homeostasis model assessment; Homa index; Hemoglobin a1c; Glycemic control; Glycated (glycosylated) hemoglobin; Glucose; Follow up; Female; Executive function test; Education; Diabetes-mellitus; Diabetes mellitus; Diabetes duration; Diabetes control; Depression; Dementia; Decline; Controlled study; Cohort analysis; Cognitive function; Cognition; Cardiovascular risk; Cardiovascular disease; Body mass; Article; Aged; Age; Adults; Adult
Resumen: IntroductionType 2 diabetes has been linked to greater cognitive decline, but other glycemic parameters such as prediabetes, diabetes control and treatment, and HOMA-IR and HbA(1c) diabetes-related biomarkers have shown inconsistent results. Furthermore, there is limited research assessing these relationships in short-term studies. Thus, we aimed to examine 2-year associations between baseline diabetes/glycemic status and changes in cognitive function in older participants at high risk of cardiovascular disease.</p> MethodsWe conducted a 2-year prospective cohort study (n=6,874) within the framework of the PREDIMED-Plus study. The participants (with overweight/obesity and metabolic syndrome; mean age 64.9 years; 48.5% women) completed a battery of 8 cognitive tests, and a global cognitive function Z-score (GCF) was estimated. At baseline, participants were categorized by diabetes status (no-diabetes, prediabetes, and <5 or >= 5-year diabetes duration), and also by diabetes control. Furthermore, insulin resistance (HOMA-IR) and glycated hemoglobin (HbA(1c)) levels were measured, and antidiabetic medications were recorded. Linear and logistic regression models, adjusted by potential confounders, were fitted to assess associations between glycemic status and changes in cognitive function.</p> ResultsPrediabetes status was unrelated to cognitive decline. However, compared to participants without diabetes, those with >= 5-year diabetes duration had greater reductions in GCF (beta=-0.11 (95%CI -0.16;-0.06)], as well as in processing speed and executive function measurements. Inverse associations were observed between baseline HOMA-IR and changes in GCF [beta=-0.0094 (95%CI -0.0164;-0.0023)], but also between HbA(1c) levels and changes in GCF [beta=-0.0085 (95%CI -0.0115, -0.0055)], the Mini-Mental State Examination, and other executive function tests. Poor diabetes control was inversely associated with phonologic fluency. The use of insulin treatment was inversely related to cognitive function as measured by the GCF [beta=-0.31 (95%CI -0.44, -0.18)], and other cognitive tests.</p> ConclusionsInsulin resistance, diabetes status, longer diabetes duration, poor glycemic control, and insulin treatment were associated with worsening cognitive function changes in the short term in a population at high cardiovascular risk.</p>
Áreas temáticas: Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Farmacia; Endocrinology, diabetes and metabolism; Endocrinology & metabolism; Ciências biológicas ii; Ciências biológicas i
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: nerea.becerra@urv.cat; monica.bullo@urv.cat; jordi.salas@urv.cat; nancy.babio@urv.cat
Fecha de alta del registro: 2025-02-08
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fendo.2021.754347/full
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Frontiers In Endocrinology. 12 754347-
Referencia de l'ítem segons les normes APA: Gomez-Martinez, Carlos; Babio, Nancy; Julvez, Jordi; Becerra-Tomas, Nerea; Martinez-Gonzalez, Miguel A; Corella, Dolores; Castaner, Olga; Romaguera, D (2021). Glycemic Dysregulations Are Associated With Worsening Cognitive Function in Older Participants at High Risk of Cardiovascular Disease: Two-Year Follow-up in the PREDIMED-Plus Study. Frontiers In Endocrinology, 12(), 754347-. DOI: 10.3389/fendo.2021.754347
DOI del artículo: 10.3389/fendo.2021.754347
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV