Autor según el artículo: Papandreou, Christopher; Harrold, Joanne A; Hansen, Thea T; Halford, Jason C G; Sjoedin, Anders; Bullo, Monica
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Bulló Bonet, Mònica
Palabras clave: Young adult Weight maintenance Weight loss Valine Triglycerides Triacylglycerol blood level Triacylglycerol Sphingomyelins Sphingomyelin Satin Satiety Satiation Prospective study Prospective studies Phosphatidylcholines Phosphatidylcholine Obesity Middle aged Metabolomics Male Major clinical study Low density lipoprotein cholesterol level Low density lipoprotein cholesterol Low calorie diet Linear models Humans Human Female Controlled study Cholesterol, ldl Cholesterol Cardiovascular risk Cardiometabolic risk factors Cardiometabolic risk factor Cardiometabolic risk Caloric restriction Body weight maintenance Body weight loss Body mass index Article Aged Adult weight maintenance weight loss satin regain metabolomics intervention disease cardiometabolic risk association
Resumen: (1) Background: There is a substantial lack of knowledge of the biochemical mechanisms by which weight loss and weight regain exert their beneficial and adverse effects, respectively, on cardiometabolic outcomes. We examined associations between changes in circulating metabolites and changes in cardiometabolic risk factors during diet-induced weight loss and weight loss maintenance. (2) Methods: This prospective analysis of data from the Satiety Innovation (SATIN) study involved adults living with overweight and obesity (mean age=47.5). One hundred sixty-two subjects achieving ?8% weight loss during an initial 8-week low-calorie diet (LCD) were included in a 12-week weight loss maintenance period. Circulating metabolites (m=123) were profiled using a targeted multiplatform approach. Data were analyzed using multivariate linear regression models. (3) Results: Decreases in the concentrations of several phosphatidylcholines (PCs), sphingomyelins (SMs), and valine were consistently associated with decreases in total (TChol) and low-density lipoprotein cholesterol (LDL-C) levels during the LCD. Increases in PCs and SMs were significantly associated with increases in TChol and LDL-C during the weight loss maintenance period. Decreases and increases in PCs during LCD and maintenance period, respectively, were associated with decreases in the levels of triglycerides. (4) Conclusions: The results of this study suggest that decreases in circulating PCs and SMs during weight loss and the subsequent weight loss maintenance period may decrease the cardiovascular risk through impacting TChol and LDL-C. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: monica.bullo@urv.cat
Identificador del autor: 0000-0002-0218-7046
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Nutrients. 13 (12): 4289-
Referencia de l'ítem segons les normes APA: Papandreou, Christopher; Harrold, Joanne A; Hansen, Thea T; Halford, Jason C G; Sjoedin, Anders; Bullo, Monica (2021). Changes in circulating metabolites during weight loss and weight loss maintenance in relation to cardiometabolic risk. Nutrients, 13(12), 4289-. DOI: 10.3390/nu13124289
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV