Autor según el artículo: Galie, Serena; Papandreou, Christopher; Arcelin, Pierre; Garcia, David; Palau-Galindo, Antoni; Gutierrez-Tordera, Laia; Folch, Alex; Bullo, Monica
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Bulló Bonet, Mònica / Galiè, Serena
Palabras clave: Rna, ribosomal, 16s Risk Randomized controlled trials as topic Omics Obesity Middle aged Microbial metabolites Metagenomics Metabolomics Metabolites Metabolism Metabolic syndrome Male Lipids Lipid metabolism Humans Host microbial interactions Gut microbiota Gastrointestinal microbiome Female Feces Diet Cross-talk Cross-sectional studies Cross-over studies Cardiovascular risk Cardiometabolic risk factors Canonical correlation analysis Association Aged Adult Acid
Resumen: (1) Background: The microbiota-host cross-talk has been previously investigated, while its role in health is not yet clear. This study aimed to unravel the network of microbial-host interactions and correlate it with cardiometabolic risk factors. (2) Methods: A total of 47 adults with overweight/obesity and metabolic syndrome from the METADIET study were included in this cross-sectional analysis. Microbiota composition (151 genera) was assessed by 16S rRNA sequencing, fecal (m = 203) and plasma (m = 373) metabolites were profiled. An unsupervised sparse generalized canonical correlation analysis was used to construct a network of microbiota-metabolite interactions. A multi-omics score was derived for each cluster of the network and associated with cardiometabolic risk factors. (3) Results: Five multi-omics clusters were identified. Thirty-one fecal metabolites formed these clusters and were correlated with plasma sphingomyelins, lysophospholipids and medium to long-chain acylcarnitines. Seven genera from Ruminococcaceae and a member from the Desulfovibrionaceae family were correlated with fecal and plasma metabolites. Positive correlations were found between the multi-omics scores from two clusters with cholesterol and triglycerides levels. (4) Conclusions: We identified a correlated network between specific microbial genera and fecal/plasma metabolites in an adult population with metabolic syndrome, suggesting an interplay between gut microbiota and host lipid metabolism on cardiometabolic health.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: monica.bullo@urv.cat
Identificador del autor: 0000-0002-0218-7046
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Nutrients. 13 (12): 4318-
Referencia de l'ítem segons les normes APA: Galie, Serena; Papandreou, Christopher; Arcelin, Pierre; Garcia, David; Palau-Galindo, Antoni; Gutierrez-Tordera, Laia; Folch, Alex; Bullo, Monica (2021). Examining the Interaction of the Gut Microbiome with Host Metabolism and Cardiometabolic Health in Metabolic Syndrome. Nutrients, 13(12), 4318-. DOI: 10.3390/nu13124318
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV