Autor según el artículo: Valls RM; Companys J; Calderón-Pérez L; Salamanca P; Pla-Pagà L; Sandoval-Ramírez BA; Bueno A; Puzo J; Crescenti A; Del Bas JM; Caimari A; Salamanca A; Espinel AE; Pedret A; Arola L; Solà R
Departamento: Medicina i Cirurgia Bioquímica i Biotecnologia
Autor/es de la URV: Arola Ferrer, Luis Maria / Companys Alemany, Judit / Pedret Figuerola, Anna / Salamanca González, Patricia / SANDOVAL RAMÍREZ, BERNER ANDRÉE / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
Palabras clave: S-allyl-l-cysteine Pulse pressure Hypercholesterolemia High blood-pressure Cardiovascular disease risk factor Blood pressure Aged garlic extract s-allyl-l-cysteine pulse pressure metaanalysis mechanisms in-vitro hypertensives hypercholesterolemia cardiovascular disease risk factor blood pressure allium-sativum adults
Resumen: The consumption of aged black garlic (ABG) has been related to improvements in several cardiovascular disease (CVD) risk factors. However, the extent of the beneficial effects depends on the garlic aging process and the amount and type of chemical compounds accumulated. The main objective of this study was to assess the effect of daily intake of a well-characterized ABG extract with a standardized S-allyl-L-cysteine (SAC) yield in combination with dietary recommendations regarding CVD risk factors in individuals with moderate hypercholesterolemia. Sixty-seven hypercholesterolemic individuals with low-density lipoprotein cholesterol levels ≥115 mg/dL were randomized in a crossover, double-blind, sustained, and controlled intervention study. The participants consumed 250 mg (1.25 mg SAC)/tablet/day ABG or a placebo for 6 weeks, with 3 weeks of washout. Blood and pulse pressure and other CVD risk biomarkers were determined at the beginning and end of each intervention. At 6 weeks, ABG extract reduced diastolic blood pressure (DBP) (mean (95% CI) −5.85 (−10.5; −1.3) mm Hg) compared to the placebo, particularly in men with a DBP > 75 mm Hg. The consumption of an improved ABG extract with 1.25 mg of SAC decreased DBP, particularly in men with moderate hypercholesterolemia. The potential beneficial effects of ABG may contribute to obtaining an optimal DBP.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: judit.companys@urv.cat anna.pedret@urv.cat lluis.arola@urv.cat rosa.sola@urv.cat rosamaria.valls@urv.cat judit.companys@urv.cat judit.companys@urv.cat patricia.salamanca@estudiants.urv.cat patricia.salamanca@estudiants.urv.cat
Identificador del autor: 0000-0003-1485-0818 0000-0002-5327-932X 0000-0003-2767-1974 0000-0002-8359-235X 0000-0002-3351-0942 0000-0003-1485-0818 0000-0003-1485-0818
Fecha de alta del registro: 2023-03-05
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2072-6643/14/3/405
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Nutrients. 14 (3):
Referencia de l'ítem segons les normes APA: Valls RM; Companys J; Calderón-Pérez L; Salamanca P; Pla-Pagà L; Sandoval-Ramírez BA; Bueno A; Puzo J; Crescenti A; Del Bas JM; Caimari A; Salamanca A (2022). Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustainedand Controlled Study. Nutrients, 14(3), -. DOI: 10.3390/nu14030405
DOI del artículo: 10.3390/nu14030405
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Tipo de publicación: Journal Publications
Repositori URV