Autor según el artículo: Soliz-Rueda JR; López-Fernández-Sobrino R; Bravo FI; Aragonès G; Suarez M; Muguerza B
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Aragonès Bargalló, Gerard / Bravo Vázquez, Francisca Isabel / López Fernández, Raul / Muguerza Marquínez, Maria Begoña / Soliz Rueda, Jorge Ricardo / Suárez Recio, Manuel
Palabras clave: Zeitgebers Seasonal rhythms Phenolic compounds High-fat diet Circadian rhythms Chrono nutrition Cafeteria diet zeitgebers seasonal rhythms rhythms phenolic compounds metabolic syndrome lipid-metabolism glucose-homeostasis expression consumption circadian rhythms circadian clock chrono nutrition cafeteria-diet body-weight gain
Resumen: Variations in the light/dark cycle and obesogenic diets trigger physiological and behavioral disorders. Proanthocyanidins, in addition to their healthy properties, have recently demonstrated a modulating effect on biological rhythms. Therefore, the aim of this study was to evaluate the administration of a grape seed proanthocyanidin-rich extract (GSPE) to mitigate the disruption caused by a sudden photoperiod change in healthy and cafeteria (CAF)-diet obese rats. For this, 48 photoperiod-sensitive Fischer 344 rats were fed standard or CAF diets for 6 weeks under a standard (12 h light/day, L12) conditions. Then, rats were switched to a long (18 h light/day, L18) or short (6 h light/day, L6) photoperiod and administered vehicle or GSPE (25 mg/kg) for 1 week. Body weight (BW) and food intake (FI) were recorded weekly. Animal activity and serum hormone concentrations were studied before and after the photoperiod change. Hormone levels were measured both at 3 h (ZT3) and 15 h (ZT15) after the onset of light. Results showed the impact of the CAF diet and photoperiod on the BW, FI, activity, and hormonal status of the animals. GSPE administration resulted in an attenuation of the changes produced by the photoperiod disruption. Specifically, GSPE in L6 CAF-fed rats reduced serum corticosterone concentration, restoring its circadian rhythm, increased the T3-to-T4 ratio, and increased light phase activity, while under L18, it decreased BW and testosterone concentration and increased the animal activity. These results suggest that GSPE may contribute to the adaptation to the new photoperiods. However, further studies are needed to elucidate the metabolic pathways and processes involved in these events.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: franciscaisabel.bravo@urv.cat begona.muguerza@urv.cat gerard.aragones@urv.cat manuel.suarez@urv.cat jorgericardo.solizr@urv.cat jorgericardo.solizr@urv.cat
Identificador del autor: 0000-0002-6468-3088 0000-0001-7384-8588 0000-0003-0122-8253
Fecha de alta del registro: 2024-01-17
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2072-6643/14/9/1834
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Nutrients. 14 (9): 1834-
Referencia de l'ítem segons les normes APA: Soliz-Rueda JR; López-Fernández-Sobrino R; Bravo FI; Aragonès G; Suarez M; Muguerza B (2022). Grape Seed Proanthocyanidins Mitigate the Disturbances Caused by an Abrupt Photoperiod Change in Healthy and Obese Rats. Nutrients, 14(9), 1834-. DOI: 10.3390/nu14091834
DOI del artículo: 10.3390/nu14091834
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Tipo de publicación: Journal Publications
Repositori URV