Repositori URV

Autor según el artículo: Alcazar, M; Escribano, J; Ferre, N; Closa-Monasterolo, R; Selma-Royo, M; Feliu, A; Castillejo, G; Luque, V

Departamento: Medicina i Cirurgia

Autor/es de la URV: Alcázar López, Mireia / Castillejo De Villasante, Gemma / Closa Monasterolo, Ricardo / Escribano Subías, Joaquín / Feliu Rovira, Albert / Ferre Pallas, Natalia / FERRÉ VALLÈS, RAIMON / Gispert Llauradó, Mariona / GUTIÉRREZ MARÍN, DESIRÉE / Luque Moreno, Verònica

Palabras clave: Risk factors Overweight Obesity Microbiota Metabolically unhealthy obesity Metabolic syndrome Intestinal microbiota Insulin sensitivity Humans Gastrointestinal microbiome Feces Epidemiology Disease Childhood obesity Child Cardiovascular diseases Cardiometabolic risk Body mass index Bacterial Anthropometry

Resumen: Background and aims: We aimed to describe and characterize the gut microbiota composition and diversity in children with obesity according to their metabolic health status. Methods: Anthropometry, Triglycerides, HDL cholesterol, HOMA-IR, and systolic and diastolic blood pressure (SBP, DBP) were evaluated (and z-score calculated) and faecal samples were collected from 191 children with obesity aged from 8 to 14. All children were classified depending on their cardiometabolic status in either a "metabolically healthy" (MHO; n = 106) or "metabolically unhealthy" (MUO; n = 85) group. Differences in gut microbiota taxonomies and diversity between groups (MUO vs MHO) were analysed. Alpha diversity index was calculated as Chao1 and Simpson's index, and b-diversity was calculated as Adonis Bray-Curtis index. Spearman's correlations and logistic regressions were performed to study the association between cardiometabolic health and the microbiota. Results: Children in the MUO presented significantly lower alpha diversity and richness than those in the MHO group (Chao1 index p = 0.021, Simpson's index p = 0.045, respectively), whereas microbiota bdiversity did not differ by the cardiometabolic health status (Adonis Bray-Curtis, R2 = 0.006; p = 0.155). The MUO group was characterized by lower relative abundances of the genera Christensenellaceae R7 group (MHO:1.42% [0.21-2.94]; MUO:0.47% [0.02-1.60], p < 0.004), and Akkermansia (MHO:0.26% [0.01 -2.19]; MUO:0.01% [0.00-0.36], p < 0.001) and higher relative abundances of Bacteroides (MHO:10.6% [4.64-18.5]; MUO:17.0% [7.18-27.4], p = 0.012) genus. After the adjustment by sex, age, and BMI, higher Akkermansia (OR: 0.86, CI: 0.75-0.97; p = 0.033), Christensenellaceae R7 group (OR: 0.86, 95% CI: 075 -0.98; p = 0.031) and Chao1 index (OR: 0.86, CI: 0.96-1.00; p = 0.023) represented a lower risk of the presence of one or more altered cardiovascular risk factors. Conclusion: Lower proportions of Christensenellaceae and Akkermansia and lower diversity and richness seem to be indicators of a metabolic unhealthy status in children with obesity. (c) 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Áreas temáticas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: veronica.luque@urv.cat mariona.gispert@iispv.cat mariona.gispert@iispv.cat gemma.castillejo@urv.cat albert.feliu@urv.cat mireia.alcazar@urv.cat ricardo.closa@urv.cat mireia.alcazar@urv.cat natalia.ferre@urv.cat joaquin.escribano@urv.cat

Identificador del autor: 0000-0003-2615-8175 0000-0002-4586-8079 0000-0002-4586-8079 0000-0001-9813-4645 0000-0002-9963-4163 0000-0001-9813-4645 0000-0002-2838-1525 0000-0002-5041-459X

Fecha de alta del registro: 2025-01-28

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Clinical Nutrition. 41 (8): 1680-1688

Referencia de l'ítem segons les normes APA: Alcazar, M; Escribano, J; Ferre, N; Closa-Monasterolo, R; Selma-Royo, M; Feliu, A; Castillejo, G; Luque, V (2022). Gut microbiota is associated with metabolic health in children with obesity. Clinical Nutrition, 41(8), 1680-1688. DOI: 10.1016/j.clnu.2022.06.007

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2022

Tipo de publicación: Journal Publications