Autor según el artículo: Gonzalez-Franquesa, Alba; Gama-Perez, Pau; Kulis, Marta; Szczepanowska, Karolina; Dahdah, Norma; Moreno-Gomez, Sonia; Latorre-Pellicer, Ana; Fernandez-Ruiz, Rebeca; Aguilar-Mogas, Antoni; Hoffman, Anne; Monelli, Erika; Samino, Sara; Miro-Blanch, Joan; Oemer, Gregor; Duran, Xavier; Sanchez-Rebordelo, Estrella; Schneeberger, Marc; Obach, Merce; Montane, Joel; Castellano, Giancarlo; Chapaprieta, Vicente; Sun, Wenfei; Navarro, Lourdes; Prieto, Ignacio; Castano, Carlos; Novials, Anna; Gomis, Ramon; Monsalve, Maria; Claret, Marc; Graupera, Mariona; Soria, Guadalupe; Wolfrum, Christian; Vendrell, Joan; Fernandez-Veledo, Sonia; Antonio Enriquez, Jose; Carracedo, Angel; Carlos Perales, Jose; Nogueiras, Ruben; Herrero, Laura; Trifunovic, Aleksandra; Keller, Markus A; Yanes, Oscar; Sales-Pardo, Marta; Guimera, Roger; Blueher, Matthias; Ignacio Martin-Subero, Jose; Garcia-Roves, Pablo M
Departamento: Enginyeria Química Enginyeria Electrònica, Elèctrica i Automàtica Medicina i Cirurgia
Autor/es de la URV: Fernandez Veledo, Sonia / Guimera Manrique, Roger / Miró Blanch, Joan / Sales Pardo, Marta / SAMINO GENÉ, SARA / Vendrell Ortega, Juan José / Yanes Torrado, Óscar
Palabras clave: Visceral adipose tissue Two-steps bariatric surgery Oxidative stress Obesity Multi-organ approach Mitochondrial dysfunction Metabolic plasticity Metabolic fingerprint Human obesity Exercise Caloric restriction visceral adipose tissue two-steps bariatric surgery proteomics multi-organ approach mitochondrial dysfunction mice metabolism metabolic plasticity metabolic fingerprint links inflammation increases human obesity gene-expression exercise dysfunction diet caloric restriction
Resumen: Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and overnutrition-related pathological features were successfully reverted, we observed a high degree of metabolic dysfunction in visceral white adipose tissue, characterized by abnormal mitochondrial morphology and functionality. Despite two sequential therapeutic interventions and an apparent global healthy phenotype, obesity triggered a cascade of events in visceral adipose tissue progressing from mitochondrial metabolic and proteostatic alterations to widespread cellular stress, which compromises its biosynthetic and recycling capacity. In humans, weight loss after bariatric surgery showed a transcriptional signature in visceral adipose tissue similar to our mouse model of obesity reversion. Overall, our data indicate that obesity prompts a lasting metabolic fingerprint that leads to a progressive breakdown of metabolic plasticity in visceral adipose tissue.
Áreas temáticas: Química Organic chemistry Odontología Medicina ii Medicina i Farmacia Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: roger.guimera@urv.cat oscar.yanes@urv.cat sonia.fernandez@urv.cat joan.miro@estudiants.urv.cat juanjose.vendrell@urv.cat marta.sales@urv.cat
Identificador del autor: 0000-0002-3597-4310 0000-0003-3695-7157 0000-0003-2906-3788 0000-0003-3179-0554 0000-0002-6994-6115 0000-0002-8140-6525
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S2213231722001252
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Redox Biology. 54 102353-
Referencia de l'ítem segons les normes APA: Gonzalez-Franquesa, Alba; Gama-Perez, Pau; Kulis, Marta; Szczepanowska, Karolina; Dahdah, Norma; Moreno-Gomez, Sonia; Latorre-Pellicer, Ana; Fernandez (2022). Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. Redox Biology, 54(), 102353-. DOI: 10.1016/j.redox.2022.102353
DOI del artículo: 10.1016/j.redox.2022.102353
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Tipo de publicación: Journal Publications
Repositori URV