Repositori URV

Identificador: imarina:9280141

Handle: https://hdl.handle.net/20.500.11797/imarina9280141

Autores:
Martinez-Urbistondo, DiegoSan Cristobal, RodrigoSanVillares, PaulaMartinez-Gonzalez, Miguel AngelBabio, NancyCorella, Doloresdel Val, Jose LuisOrdovas, Jose MAlonso-Gomez, Angel MWarnberg, JuliaVioque, JesusRomaguera, DoraLopez-Miranda, JoseEstruch, RamonTinahones, Francisco JLapetra, JoseSerra-Majem, J LuisBueno-Cavanillas, AuroraTur, Josep AMarcos, AlbaPinto, XavierDelgado-Rodriguez, MiguelMatia-Martin, PilarVidal, JosepVazquez, ClotildeRos, EmilioVela, Maria Vanessa BullonPalau, AntoniMasague, MartaAbete, ItziarMoreno-Rodriguez, AnaiCandela-Garcia, InmaKonieczna, JadwigaGarcia-Rios, AntonioJuarez, Oscar LeceaMartin, PacoGoday, AlbertZulet, M AngelesVaquero-Luna, JessicaOrea, Maria del Carmen SayonMegias, IsabelBaltasar, EnricMartinez, J AlfredoDaimiel, Lidia

Resumen:
Objective: To evaluate the effect of Non-alcoholic fatty liver disease (NAFLD) status in the impact of lifestyle over Health-related quality of life (HRQoL) in patients with metabolic syndrome (MetS). Methods: Baseline and 1 year follow up data from the PREDIMED-plus cohort (men and women, 55-75 years old with overweight/obesity and MetS) were studied. Adherence to an energy-restricted Mediterranean Diet (er-MeDiet) and Physical Activity (PA) were assessed with a validated screeners. Hepatic steatosis index (HSI) was implemented to evaluate NAFLD while the SF-36 questionnaire provided HRQoL evaluation. Statistical analyses were performed to evaluate the influence of baseline NAFLD on HRQoL as affected by lifestyle during 1 year of follow up. Results: Data from 5205 patients with mean age of 65 years and a 48% of female participants. Adjusted linear multivariate mixed regression models showed that patients with lower probability of NAFLD (HSI < 36 points) were more responsive to er-MeDiet (β 0.64 vs β 0.05 per er-MeDiet adherence point, p< 0.01) and PA (β 0.05 vs β 0.01 per MET-h/week, p = 0.001) than those with high probability for NAFLD in terms Physical SF-36 summary in the 1 year follow up. 10 points of er-MeDiet adherence and 50 MET-h/week were thresholds for a beneficial effect of lifestyle on HRQoL physical domain in patients with lower probability of NAFLD. Conclusion: The evaluation of NAFLD by the HSI index in patients with MetS might identify subjects with different prospective sensitivity to lifestyle changes in terms of physical HRQoL (http://www.isrctn.com/ISRCTN89898870).