Autor según el artículo: Biosca-Brull J; Guardia-Escote L; Blanco J; Basaure P; Cabré M; Sánchez-Santed F; Domingo JL; Colomina MT
Departamento: Psicologia Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
Autor/es de la URV: BASAURE GARCÍA, PÍA ISABEL / Biosca Brull, Judit / Blanco Pérez, Jordi / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / Guardia Escoté, Laia
Palabras clave: autism brain-regions developmental neurotoxicity excitatory female mice gaba gene-expression glutamate inhibitory balance messenger-rna levels rat-brain receptor social behavior Autism Cerebellar purkinje-cells Chlorpyrifos Excitatory/inhibitory balance Gaba Glutamate Social behavior
Resumen: The balance between excitatory and inhibitory neurotransmitters is essential for proper brain development. An imbalance between these two systems has been associated with neurodevelopmental disorders. On the other hand, literature also associates the massive use of pesticides with the increase of these disorders, with a particular focus on chlorpyrifos (CPF) a world-wide used organophosphate pesticide. This study was aimed at assessing social autistic-like behaviors on mice pre or postnatally exposed to CPF (0 or 1 mg/kg/day), in both sexes. In prenatal exposure, C57BL/6J pregnant mice were exposed to CPF through the diet, between gestational days (GD) 12 and 18, while a positive control group for some autistic behaviors was exposed to valproic acid (VPA) on GD 12 and 13. To assess postnatal exposure, C57BL/6J mice were orally exposed to the vehicle (corn oil) or CPF, from postnatal days (PND) 10–15. Social behavior and gene expression analysis were assessed on PND 45. Results showed social alterations only in males prenatally treated. GABA system was upregulated in CPF-treated females, whereas an increase in both systems was observed in both treated males. These findings suggest that males are more sensitive to prenatal CPF exposure, favoring the sex bias observed in ASD.
Áreas temáticas: Astronomia / física Biodiversidade Biotecnología Ciência de alimentos Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Educação física Enfermagem Engenharias ii Engenharias iv Ensino Farmacia Food science Food science & technology Interdisciplinar Materiais Medicina i Medicina ii Medicina iii Medicina veterinaria Medicine (miscellaneous) Nutrição Odontología Química Saúde coletiva Toxicology
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: maria.cabre@urv.cat judit.biosca@urv.cat joseluis.domingo@urv.cat mariateresa.colomina@urv.cat jordi.blanco@urv.cat judit.biosca@urv.cat
Identificador del autor: 0000-0003-4124-8603 0000-0001-6647-9470 0000-0002-5619-4874 0000-0001-8016-0984
Fecha de alta del registro: 2023-02-23
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0278691522006214?via%3Dihub
Referencia al articulo segun fuente origial: Food And Chemical Toxicology. 169 113423-
Referencia de l'ítem segons les normes APA: Biosca-Brull J; Guardia-Escote L; Blanco J; Basaure P; Cabré M; Sánchez-Santed F; Domingo JL; Colomina MT (2022). Prenatal, but not postnatal exposure to chlorpyrifos affects social behavior of mice and the excitatory-inhibitory balance in a sex-dependent manner. Food And Chemical Toxicology, 169(), 113423-. DOI: 10.1016/j.fct.2022.113423
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1016/j.fct.2022.113423
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Tipo de publicación: Journal Publications
Repositori URV