Autor según el artículo: Rubín-García M; Vitelli-Storelli F; Álvarez-álvarez L; Martínez-González MÁ; Salas-Salvadó J; Corella D; Hernáez Á; Martínez JA; Alonso-Gómez ÁM; Wärnberg J; Vioque J; Romaguera D; López-Miranda J; Estruch R; Tinahones FJ; Serra-Majem LI; Cano-Ibañez N; Tur JA; Marcos-Delgado A; Tresserra-Rimbau A; Pintó X; Delgado-Rodríguez M; Matía-Martín P; Vidal J; Vázquez C; Daimiel L; Ros E; Vázquez-Ruiz Z; Babio N; Barragán R; Castañer-Niño O; Razquin C; Tojal-Sierra L; Gómez-Gracia E; González-Palacios S; Morey M; García-Rios A; Castro-Barquero S; Bernal-López MR; Santos-Lozano JM; Ruiz-Canela M; Castro-Salomó A; Pascual-Castelló EC; Moldon V; Bullón-Vela V; Sorto-Sanchez C; Cenoz-Osinaga JC; Gutiérrez L; Mengual M; Lamuela-Raventós RM; Martín-Sánchez V
Departamento: Medicina i Cirurgia Bioquímica i Biotecnologia
Autor/es de la URV: Babio Sánchez, Nancy Elvira / Castro Salomó, Antoni / Salas Salvadó, Jorge
Palabras clave: Uric acid Polyphenols Hyperuricemia Food-frequency questionnaire validation uric acid polyphenols metabolic syndrome mediterranean diet mechanism inverse association health gout flavonoids coffee consumption
Resumen: Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, -0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, -0.27 to -0.06]) and hydroxycinnamic acids (β coefficient, -0.19 [95% CI, -0.3 to -0.09]), alkylmethoxyphenols (β coefficient, -0.2 [95% CI, -0.31 to -0.1]), and methoxyphenols (β coefficient, -0.24 [95% CI, -0.34 to -0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.80 [95% CI, 0.70-0.92]; and PR, 0.79 [95% CI, 0.69-0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02-0.26]) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research.
Áreas temáticas: Saúde coletiva Nutrição Medicina ii Medicina i Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: antoni.castro@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Identificador del autor: 0000-0001-5441-6333 0000-0003-2700-7459 0000-0003-3527-5277
Fecha de alta del registro: 2024-08-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.ahajournals.org/doi/10.1161/JAHA.122.026053
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Journal Of The American Heart Association. 11 (20): e026053-e026053
Referencia de l'ítem segons les normes APA: Rubín-García M; Vitelli-Storelli F; Álvarez-álvarez L; Martínez-González MÁ; Salas-Salvadó J; Corella D; Hernáez Á; Martínez JA; Alonso-Gómez ÁM; Wärn (2022). Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk. Journal Of The American Heart Association, 11(20), e026053-e026053. DOI: 10.1161/JAHA.122.026053
DOI del artículo: 10.1161/JAHA.122.026053
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Tipo de publicación: Journal Publications
Repositori URV