Articles producció científica> Enginyeria Química

Binding of calix[4]pyrroles to pyridine N-oxides probed with surface plasmon resonance

  • Datos identificativos

    Identificador: imarina:9282521
    Autores:
    Adriaenssens LAcero Sánchez JLBarril XO'Sullivan CKBallester P
    Resumen:
    Using a commercial instrument that integrates microfluidics with surface plasmon resonance (SPR) detection, we thermodynamically and kinetically characterise the interactions of water-soluble calix[4]pyrroles with surface-immobilized guests derived from pyridine N-oxide. This technique provides detailed information in real time and shows that, while thermodynamically similar, the binding process occurring with the surface-immobilised guests is kinetically very different to that in solution. Two different binding processes can be distinguished for the surface-immobilised guests. Both complexation processes provide 1:1 complexes with thermodynamic stabilities that are similar to each other and to the 1:1 complex formed in solution. However, the kinetic stabilities of the complexes formed with the surface anchored ligands are significantly higher. These observations are rationalized on the basis of the effects exerted by the dextran matrix employed for the ligand's immobilisation on the small molecule complexes that are formed. This journal is © the Partner Organisations 2014.
  • Otros:

    Autor según el artículo: Adriaenssens L; Acero Sánchez JL; Barril X; O'Sullivan CK; Ballester P
    Departamento: Enginyeria Química
    Autor/es de la URV: ACERO SÁNCHEZ, JOSEP LLUÍS / O'SULLIVAN, CIARA KATHLEEN
    Palabras clave: Pyridine n-oxides
    Resumen: Using a commercial instrument that integrates microfluidics with surface plasmon resonance (SPR) detection, we thermodynamically and kinetically characterise the interactions of water-soluble calix[4]pyrroles with surface-immobilized guests derived from pyridine N-oxide. This technique provides detailed information in real time and shows that, while thermodynamically similar, the binding process occurring with the surface-immobilised guests is kinetically very different to that in solution. Two different binding processes can be distinguished for the surface-immobilised guests. Both complexation processes provide 1:1 complexes with thermodynamic stabilities that are similar to each other and to the 1:1 complex formed in solution. However, the kinetic stabilities of the complexes formed with the surface anchored ligands are significantly higher. These observations are rationalized on the basis of the effects exerted by the dextran matrix employed for the ligand's immobilisation on the small molecule complexes that are formed. This journal is © the Partner Organisations 2014.
    Áreas temáticas: Astronomia / física Chemistry (all) Chemistry (miscellaneous) Chemistry, multidisciplinary Ciências biológicas i Ciências biológicas iii Farmacia General chemistry Interdisciplinar Materiais Química
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: ciara.osullivan@urv.cat
    Identificador del autor: 0000-0002-0965-4655 0000-0003-2603-2230
    Fecha de alta del registro: 2022-10-15
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://pubs.rsc.org/en/content/articlelanding/2014/sc/c4sc01745e
    Referencia al articulo segun fuente origial: Chemical Science. 5 (11): 4210-4215
    Referencia de l'ítem segons les normes APA: Adriaenssens L; Acero Sánchez JL; Barril X; O'Sullivan CK; Ballester P (2014). Binding of calix[4]pyrroles to pyridine N-oxides probed with surface plasmon resonance. Chemical Science, 5(11), 4210-4215. DOI: 10.1039/c4sc01745e
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1039/c4sc01745e
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2014
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Chemistry (Miscellaneous),Chemistry, Multidisciplinary
    Pyridine n-oxides
    Astronomia / física
    Chemistry (all)
    Chemistry (miscellaneous)
    Chemistry, multidisciplinary
    Ciências biológicas i
    Ciências biológicas iii
    Farmacia
    General chemistry
    Interdisciplinar
    Materiais
    Química
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