Autor según el artículo: Wang Z; Mithieux SM; Vindin H; Wang Y; Zhang M; Liu L; Zbinden J; Blum KM; Yi T; Matsuzaki Y; Oveissi F; Akdemir R; Lockley KM; Zhang L; Ma K; Guan J; Waterhouse A; Pham NTH; Hawkett BS; Shinoka T; Breuer CK; Weiss AS
Departamento: Enginyeria Química
Autor/es de la URV: Akdemir, Reyda
Palabras clave: Vascular grafts Tropoelastin Tissue engineering Shear-stress Regenerative medicine Polyglycerol sebacate Nitric-oxide synthase Internal elastic lamina Hypertension Haploinsufficiency Expression Endothelium Elastin Elastic lamellae Collagen Blood-pressure
Resumen: Native arteries contain a distinctive intima-media composed of organized elastin and an adventitia containing mature collagen fibrils. In contrast, implanted biodegradable small-diameter vascular grafts do not present spatially regenerated, organized elastin. The elastin-containing structures within the intima-media region encompass the elastic lamellae (EL) and internal elastic lamina (IEL) and are crucial for normal arterial function. Here, the development of a novel electrospun small-diameter vascular graft that facilitates de novo formation of a structurally appropriate elastin-containing intima-media region following implantation is described. The graft comprises a non-porous microstructure characterized by tropoelastin fibers that are embedded in a PGS matrix. After implantation in mouse abdominal aorta, the graft develops distinct cell and extracellular matrix profiles that approximate the native adventitia and intima-media by 8 weeks. Within the newly formed intima-media region there are circumferentially aligned smooth muscle cell layers that alternate with multiple EL similar to that found in the arterial wall. By 8 months, the developed adventitia region contains mature collagen fibrils and the neoartery presents a distinct IEL with thickness comparable to that in mouse abdominal aorta. It is proposed that this new class of material can generate the critically required, organized elastin needed for arterial regeneration.
Áreas temáticas: Química Physics, condensed matter Physics, applied Nanoscience and nanotechnology Nanoscience & nanotechnology Medicina ii Mechanics of materials Mechanical engineering Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) Materials science Materiais Interdisciplinar General materials science Engenharias iv Engenharias iii Engenharias ii Chemistry, physical Chemistry, multidisciplinary Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: reyda.akdemir-@estudiants.urv.cat reyda.akdemir-@estudiants.urv.cat
Identificador del autor: 0000-0001-9359-5012 0000-0001-9359-5012
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/full/10.1002/adma.202205614
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Advanced Materials. 34 (47):
Referencia de l'ítem segons les normes APA: Wang Z; Mithieux SM; Vindin H; Wang Y; Zhang M; Liu L; Zbinden J; Blum KM; Yi T; Matsuzaki Y; Oveissi F; Akdemir R; Lockley KM; Zhang L; Ma K; Guan J; (2022). Rapid Regeneration of a Neoartery with Elastic Lamellae. Advanced Materials, 34(47), -. DOI: 10.1002/adma.202205614
DOI del artículo: 10.1002/adma.202205614
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Tipo de publicación: Journal Publications