Autor según el artículo: Farras, Marta; Swann, Jonathan Richard; Rowland, Ian; Rubio, Laura; Subirana, Isaac; Catalan, Ursula; Jose Motilva, Maria; Sola, Rosa; Covas, Maria Isabel; Blanco-Vaca, Francisco; Fito, Montserrat; Mayneris-Perxachs, Jordi;
Departamento: Medicina i Cirurgia
Autor/es de la URV: Catalán Santos, Úrsula
Palabras clave: Selection Risk Promotes Profile Polyphenols enhance Phenolic compounds Metabonomics Hypercholesterolemic subjects. Functional olive oil Endothelial function Cardiovascular-disease Cardiovascular diseases Branched-chain Amino-acids
Resumen: Phenol-rich foods consumption such as virgin olive oil (VOO) has been shown to have beneficial effects on cardiovascular diseases. The broader biochemical impact of VOO and phenol-enriched OOs remains, however, unclear. A randomized, double-blind, cross-over, controlled trial was performed with thirty-three hypercholesterolemic individuals who ingested for 3-weeks (25 mL/day): (1) an OO enriched with its own olive oil phenolic compounds (PCs) (500 ppm; FOO); (2) an OO enriched with its own olive oil PCs (250 ppm) plus thyme PCs (250 ppm; FOOT); and (3) a VOO with low phenolic content (80 ppm). Serum lipid and glycemic profiles, serum H-1-NMR spectroscopy-based metabolomics, endothelial function, blood pressure, and cardiovascular risk were measured. We combined OPLS-DA with machine learning modelling to identify metabolites discrimination of the treatment groups. Both phenol-enriched OO interventions decreased the levels of glutamine, creatinine, creatine, dimethylamine, and histidine in comparison to VOO one. In addition, FOOT decreased the plasma levels of glycine and DMSO2 compared to VOO, while FOO decreased the circulating alanine concentrations but increased the plasma levels of acetone and 3-HB compared to VOO. Based on these findings, phenol-enriched OOs were shown to result in a favorable shift in the circulating metabolic phenotype, inducing a reduction in metabolites associated with cardiometabolic diseases.
Áreas temáticas: Química Physiology Molecular biology Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Engenharias ii Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: ursula.catalan@urv.cat
Identificador del autor: 0000-0001-8884-9823
Fecha de alta del registro: 2023-08-05
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2076-3921/11/10/1964
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Antioxidants. 11 (10):
Referencia de l'ítem segons les normes APA: Farras, Marta; Swann, Jonathan Richard; Rowland, Ian; Rubio, Laura; Subirana, Isaac; Catalan, Ursula; Jose Motilva, Maria; Sola, Rosa; Covas, Maria Is (2022). Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial. Antioxidants, 11(10), -. DOI: 10.3390/antiox11101964
DOI del artículo: 10.3390/antiox11101964
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Tipo de publicación: Journal Publications
Repositori URV